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Avian Dis. 2003;47(3 Suppl):888-97. doi: 10.1637/0005-2086-47.s3.888.
2
Avian influenza virus subtypes inside and outside the live bird markets, 1993-2000: a spatial and temporal relationship.1993 - 2000年活禽市场内外的禽流感病毒亚型：时空关系
Avian Dis. 2002 Apr-Jun;46(2):298-307. doi: 10.1637/0005-2086(2002)046[0298:AIVSIA]2.0.CO;2.
3
Changes in the haemagglutinin and the neuraminidase genes prior to the emergence of highly pathogenic H7N1 avian influenza viruses in Italy.意大利高致病性H7N1禽流感病毒出现之前血凝素和神经氨酸酶基因的变化。
Arch Virol. 2001;146(5):963-73. doi: 10.1007/s007050170128.
4
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Arch Virol. 2000;145(5):1047-58. doi: 10.1007/s007050050695.
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Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth: a study by reverse genetics.血凝素糖基化与神经氨酸酶作为流感病毒生长调节因子的相互依赖性：反向遗传学研究
J Virol. 2000 Jul;74(14):6316-23. doi: 10.1128/jvi.74.14.6316-6323.2000.
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A review of avian influenza in different bird species.不同鸟类物种中的禽流感综述。
Vet Microbiol. 2000 May 22;74(1-2):3-13. doi: 10.1016/s0378-1135(00)00160-7.
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Characteristics of H7N2 (nonpathogenic) avian influenza virus infections in commercial layers, in Pennsylvania, 1997-98.1997 - 1998年宾夕法尼亚州商品蛋鸡群中H7N2（非致病性）禽流感病毒感染的特征
Avian Dis. 1999 Jan-Mar;43(1):142-9.
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Phylogenetic analysis of H7 avian influenza viruses isolated from the live bird markets of the Northeast United States.对从美国东北部活禽市场分离出的H7禽流感病毒进行系统发育分析。
J Virol. 1999 May;73(5):3567-73. doi: 10.1128/JVI.73.5.3567-3573.1999.
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Rapid evolution of H5N1 influenza viruses in chickens in Hong Kong.香港鸡群中H5N1流感病毒的快速进化。
J Virol. 1999 Apr;73(4):3366-74. doi: 10.1128/JVI.73.4.3366-3374.1999.
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The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.从人类、鸡和野生水禽中分离出的H5流感病毒的表面糖蛋白具有可区分的特性。
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对与美国商业家禽中三次不同疫情相关的近期H7禽流感病毒进行的序列分析。

Sequence analysis of recent H7 avian influenza viruses associated with three different outbreaks in commercial poultry in the United States.

作者信息

Spackman Erica, Senne Dennis A, Davison Sherrill, Suarez David L

机构信息

Southeast Poultry Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Athens, Georgia 30605, USA.

出版信息

J Virol. 2003 Dec;77(24):13399-402. doi: 10.1128/jvi.77.24.13399-13402.2003.

DOI:10.1128/jvi.77.24.13399-13402.2003
PMID:14645595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC296076/
Abstract

The hemagglutinin (HA) and neuraminidase (NA) genes of H7 avian influenza virus (AIV) isolated between 1994 and 2002 from live-bird markets (LBMs) in the northeastern United States and from three outbreaks in commercial poultry have been characterized. Phylogenetic analysis of the HA and NA genes demonstrates that the isolates from commercial poultry were closely related to the viruses circulating in the LBMs. Also, since 1994, two distinguishing genetic features have appeared in this AIV lineage: a deletion of 17 amino acids in the NA protein stalk region and a deletion of 8 amino acids in the HA1 protein which is putatively in part of the receptor binding site. Furthermore, analysis of the HA cleavage site amino acid sequence, a marker for pathogenicity in chickens and turkeys, shows a progression toward a cleavage site sequence that fulfills the molecular criteria for highly pathogenic AIV.

摘要

对1994年至2002年间从美国东北部活禽市场（LBM）以及三次商业家禽疫情中分离出的H7禽流感病毒（AIV）的血凝素（HA）和神经氨酸酶（NA）基因进行了特征分析。对HA和NA基因的系统发育分析表明，来自商业家禽的分离株与LBM中传播的病毒密切相关。此外，自1994年以来，该AIV谱系出现了两个显著的遗传特征：NA蛋白茎区缺失17个氨基酸，HA1蛋白中缺失8个氨基酸，推测这部分位于受体结合位点。此外，对HA裂解位点氨基酸序列（鸡和火鸡致病性的一个标志物）的分析表明，其裂解位点序列正朝着符合高致病性AIV分子标准的方向发展。