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生活质量理念三。迈向新生物学:理解生活质量、疾病与治愈之间的生物学联系。

Quality of life philosophy III. Towards a new biology: understanding the biological connection between quality of life, disease, and healing.

作者信息

Ventegodt Søren, Andersen Niels Jørgen, Merrick Joav

机构信息

The quality of Life Research Center, Copenhagen, Denmark.

出版信息

ScientificWorldJournal. 2003 Dec 1;3:1186-98. doi: 10.1100/tsw.2003.103.

Abstract

This paper addresses (in a philosophical way) the complex and enigmatic interface between matter, life, and consciousness in modern medical science. The problem today in understanding living matter is not at the molecular level, but at the macro level where all molecular activities in the individual cell are coordinated, and especially at a higher level, where the activities of all the organism"s cells are coordinated. Although we understand very much of the body"s chemistry, we have only just started to get the gist of the tremendous organization of living matter. We are just beginning to acknowledge the enormous flow of information that is needed to make everything function in a healthy organism, including consciousness, where every cell does exactly what it has to do to make the organs function. A concept that seems to be able to bridge the scientifically very different domains of matter, life, and consciousness seems to be "biological information". If a cell is seen as a liquid crystal in which the cell"s molecules constantly connect in firm mutual relationships only to dissolve again and become fluid and free, whenever the cell needs it, the backbone of the cell seems to be the information that organizes the cell. For example, in cell motion a cell is able to crawl with the help of a skeleton of fibers that can be created guided by biological information, whenever the cell needs the solidity provided by the fibers. The moment it has finished crawling or intends to crawl in another direction, these fibers will dissolve again. The fibers are made of millions of molecules that connect in an arranged pattern, and they dissolve when these molecules again let go of each other. How the cell precisely regulates such processes is today a complete mystery. How cells cocreate consciousness is also an enigma. All we can do is describe the cell and the organisms arising from its cells as filled with energy and information as well as an unbeatable ability to organize itself way down to the molecular level, where apparently the cell is in control of almost every single molecule. Our understanding today of how the information is stored and how it flows through living matter is still very limited. The source of the qualities (the qualia) characterizing the human being as a whole--like joy, love, motivation, consciousness, free will, wisdom, intuitive competence--is still practically unknown and scientifically unexplained, more than 50 years after science has turned itself towards these fundamental problems. We believe that we need a radically new biology and medicine to give the scientific explanations of the structure, dynamics, and quality of life, and of its consciousness.

摘要

本文(以哲学的方式)探讨了现代医学科学中物质、生命和意识之间复杂而神秘的界面。如今,理解生命物质的问题并非处于分子层面,而是在宏观层面,即单个细胞内所有分子活动在此协调,尤其在更高层面,即生物体所有细胞的活动在此协调。尽管我们对人体化学有了很多了解,但我们才刚刚开始领会生命物质惊人的组织性。我们才刚刚开始认识到,要使包括意识在内的健康生物体中的一切正常运转,需要大量的信息流,其中每个细胞都精确地履行其职责以确保器官正常运作。一个似乎能够弥合物质、生命和意识在科学上截然不同领域的概念似乎是“生物信息”。如果将细胞视为一种液晶,其中细胞分子不断以稳固的相互关系连接,然后又溶解,变回流动和自由状态,只要细胞有需要,那么细胞的核心似乎就是组织细胞的信息。例如,在细胞运动中,细胞能够借助由生物信息引导生成的纤维骨架爬行,只要细胞需要纤维提供的稳固性。一旦它完成爬行或打算向另一个方向爬行,这些纤维就会再次溶解。这些纤维由数百万个以有序模式连接的分子组成,当这些分子彼此松开时它们就会溶解。细胞如何精确调节这些过程如今完全是个谜。细胞如何共同创造意识也是一个谜。我们所能做的只是将细胞以及由其产生的生物体描述为充满能量、信息以及一种无与伦比的自我组织能力,这种能力一直延伸到分子层面,显然在这个层面细胞几乎控制着每一个分子。我们如今对信息如何存储以及如何在生命物质中流动的理解仍然非常有限。在科学转向这些基本问题五十多年后,构成整个人类特征的特质(感受质),如喜悦、爱、动机、意识、自由意志、智慧、直觉能力的来源实际上仍然未知,且在科学上无法解释。我们认为,我们需要一门全新的生物学和医学来对生命的结构、动态、质量及其意识给出科学解释。

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