Tanioka Y, Yoshida T, Yagawa T, Saiki Y, Takeo S, Harada T, Okazawa T, Yanai H, Okita K
Department of Gastroenterology and Hepatology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Br J Cancer. 2003 Dec 1;89(11):2116-21. doi: 10.1038/sj.bjc.6601372.
If oesophageal carcinoma is detected in the superficial stage, the prognosis is better than for advanced oesophageal carcinoma. But the factors which predict the prognosis and treatment policy remain unclear. Matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) have been reported to have close associations with tumour invasion and metastasis. In this study, we retrospectively studied the relations between MMP-7 and MMP-9 expression in immunohistochemistry, clinicopathologic factors, and prognosis in 55 superficial oesophageal carcinomas. MMP-7 and MMP-9 expression occurred in 23.6% and 47.3% of the patients, respectively. MMP-7 expression was significantly correlated with the presence of nodal metastasis (P=0.004). MMP-9 expression was significantly correlated with the depth of tumour invasion (P=0.004), lymphatic permeation (P=0.001), nodal metastasis (P=0.049), and pathologic differentiation grade (P=0.003). By the log-rank test, MMP-7 expression and MMP-9 expression on the invasive front were related to the prognosis. In multivariate analysis, MMP-9 expression on the invasive front was an independent prognostic indicator. The combined expression of MMP-7 and MMP-9 may be a good marker for the degree of malignancy of oesophageal cancer and for the presence of lymphatic metastasis.
如果在浅表阶段检测到食管癌，其预后优于晚期食管癌。但预测预后和治疗策略的因素仍不明确。据报道，基质金属蛋白酶-7（MMP-7）和基质金属蛋白酶-9（MMP-9）与肿瘤侵袭和转移密切相关。在本研究中，我们回顾性研究了55例浅表食管癌患者免疫组化中MMP-7和MMP-9表达、临床病理因素与预后之间的关系。MMP-7和MMP-9表达分别出现在23.6%和47.3%的患者中。MMP-7表达与淋巴结转移的存在显著相关（P=0.004）。MMP-9表达与肿瘤浸润深度（P=0.004）、淋巴管浸润（P=0.001）、淋巴结转移（P=0.049）和病理分化程度（P=0.003）显著相关。通过对数秩检验，侵袭前沿的MMP-7表达和MMP-9表达与预后相关。在多变量分析中，侵袭前沿的MMP-9表达是一个独立的预后指标。MMP-7和MMP-9的联合表达可能是食管癌恶性程度和淋巴转移存在的良好标志物。
