Morris A M, So Y, Lee K A, Lash A A, Becker C E
Center for Occupational and Environmental Health, University of California, San Francisco.
J Occup Med. 1992 Dec;34(12):1143-52.
We monitored 15 healthy young adults during 18 hours of sleep deprivation. Subjects were repeatedly tested on measures of the P300 (P3) event-related potential, reaction time, body temperature, and a subjective rating of fatigue. Statistically significant decreases in P3 amplitude (P < or = .01) and increases in P3 latency (P < or = .0001) were found during sleep deprivation. These changes correlated with body temperature and fatigue and were not due to circadian variation. Reaction time did not show a significant change over time. We conclude that the P3 potential is a more sensitive cognitive measure of sleep deprivation than reaction time, a measure commonly used in previous studies. We provide a review of the literature on the P3 and recommend the use of the P3 as a marker to examine sleep deprivation in health professionals.
我们对15名健康的年轻成年人进行了18小时睡眠剥夺期间的监测。受试者在P300（P3）事件相关电位、反应时间、体温以及疲劳主观评分等指标上接受了多次测试。在睡眠剥夺期间，发现P3波幅有统计学意义的下降（P≤0.01），P3潜伏期增加（P≤0.0001）。这些变化与体温和疲劳相关，并非昼夜节律变化所致。反应时间随时间未显示出显著变化。我们得出结论，P3电位是比反应时间更敏感的睡眠剥夺认知指标，反应时间是先前研究中常用的指标。我们对有关P3的文献进行了综述，并建议将P3用作检查健康专业人员睡眠剥夺情况的标志物。
