Erdamar B, Suoglu Y, Sirin M, Karatay C, Katircioglu S, Kiyak E
University of Istanbul, Faculty of Medicine, Department of Otorhinolaryngology, Turkey.
Eur Arch Otorhinolaryngol. 2000;257(3):154-7. doi: 10.1007/s004050050213.
Basaloid squamous cell carcinoma (BSC) is regarded as a variant of squamous cell carcinoma, but displays distinct morphological and biological features as well as a different clinical course. The tumor is frequently seen in the head and neck and is preferentially located in the larynx, especially in supraglottic sites. Ten patients with BSC of the supraglottic larynx were treated from 1991 to 1995 at the Medical Faculty of the University of Istanbul. Results of treatment were compared retrospectively with a control group consisting of 44 patients with well-differentiated squamous cell carcinomas. Ages, localizations, stages and treatment procedures were similar. In both groups mean survival, nodal involvement and distant metastases were comparable although the local (laryngeal) recurrence rate in patients with early supraglottic (T2) disease in the BSC group after conservative partial surgery was distinct compared to the control group (P < 0.05). These results indicate that conservative surgery should be assessed with caution in patients with BSC, and postoperative irradiation be taken into consideration.
基底样鳞状细胞癌（BSC）被视为鳞状细胞癌的一种变体，但具有独特的形态学和生物学特征以及不同的临床病程。该肿瘤常见于头颈部，尤其好发于喉部，特别是声门上区。1991年至1995年期间，伊斯坦布尔大学医学院对10名声门上区BSC患者进行了治疗。将治疗结果与由44名高分化鳞状细胞癌患者组成的对照组进行回顾性比较。两组患者的年龄、病变部位、分期和治疗方法相似。尽管BSC组早期声门上区（T2）疾病患者在保守性部分手术后的局部（喉部）复发率与对照组相比有显著差异（P < 0.05），但两组的平均生存期、淋巴结受累情况和远处转移情况相当。这些结果表明，对于BSC患者，应谨慎评估保守性手术，并考虑术后放疗。
