Rothe A, Seibold M, Hoppe Th, Seifert H, Engert A, Caspar C, Karthaus M, Fätkenheuer G, Bethe U, Tintelnot K, Cornely O A
Klinik I für Innere Medizin, Universität zu Köln, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany.
Ann Hematol. 2004 Jun;83(6):394-7. doi: 10.1007/s00277-003-0795-x. Epub 2003 Nov 27.
A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.
报告了1例急性髓系白血病化疗后播散性尖孢镰刀菌感染病例。抗真菌治疗成功，采用口服特比萘芬250 mg每日3次，疗程13天，联合脱氧胆酸盐两性霉素B 1.0 - 1.5 mg/kg每日1次，随后静脉注射脂质体两性霉素B 5 mg/kg每日1次。之前采用脱氧胆酸盐两性霉素B 1.0 - 1.5 mg/kg每日1次的单一疗法未能阻止感染进展。本文所述的联合疗法是治疗免疫功能低下宿主中镰刀菌属感染的一种新方法，已知镰刀菌属在这类宿主中可引起播散性感染，死亡率很高。
