de Souza Marcela, Matsuzawa Tetsuhiro, Lyra Luzia, Busso-Lopes Ariane Fidelis, Gonoi Tohru, Schreiber Angélica Zaninele, Kamei Katsuhiko, Moretti Maria Luiza, Trabasso Plínio
Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, São Paulo Brazil ; LIM 46 - Laboratory of Parasitology - HC/FMUSP, Kragujevac, São Paulo Brazil.
Medical Mycology Research Center, Chiba University, Chiba, Japan.
Springerplus. 2014 Aug 30;3:492. doi: 10.1186/2193-1801-3-492. eCollection 2014.
During the last decades, Fusarium spp. has been reported as a significant cause of disease in humans, especially in immunocompromised patients, who have high risk of invasive life-threatening disease. Fusarium species usually reported as cause of human disease are F. solani, F. oxysporum and F. verticillioides.
We describe the second case in the literature of disseminated fusariosis caused by Fusarium napiforme, that occurred in a 60-year-old woman with multiple myeloma after subsequent cycles of chemotherapy.
We identified the F. napiforme not only by standard morphologic criteria by macroscopic and microscopic characteristics, but also confirmed by molecular biology methods, including sequencing. The antifungal susceptibility of the F. napiforme isolates were tested to seven antifungal drugs; the azoles were the most active drug against all the isolates tested.
Fusarium spp. are of relevance in medical mycology, and their profiles of low susceptibility to antifungal drugs highlight the importance for faster and more accurate diagnostic tests, what can contribute to an earlier and precise diagnosis and treatment.
在过去几十年中，镰刀菌属已被报道为人类疾病的重要病因，尤其是在免疫功能低下的患者中，这些患者有发生危及生命的侵袭性疾病的高风险。通常被报道为人类疾病病因的镰刀菌种类有茄病镰刀菌、尖孢镰刀菌和轮枝镰刀菌。
我们描述了文献中第二例由瓶梗镰刀菌引起的播散性镰刀菌病病例，该病例发生在一名60岁的多发性骨髓瘤女性患者身上，该患者在后续化疗周期后发病。
我们不仅通过宏观和微观特征的标准形态学标准鉴定了瓶梗镰刀菌，还通过包括测序在内的分子生物学方法进行了确认。对瓶梗镰刀菌分离株进行了七种抗真菌药物的药敏试验；唑类药物是对所有测试分离株最有效的药物。
镰刀菌属在医学真菌学中具有重要意义，它们对抗真菌药物低敏感性的特征凸显了更快、更准确诊断测试的重要性，这有助于早期准确的诊断和治疗。
