Poyrazoğlu Hakan M, Düşünsel Ruhan, Gündüz Zübeyde, Patiroğlu Türkan, Köklü Selmin
Department of Pediatric Nephrology, Medical Faculty, Erciyes University, 38039 Kayseri, Turkey.
Pediatr Nephrol. 2004 Jan;19(1):57-60. doi: 10.1007/s00467-003-1301-3. Epub 2003 Nov 25.
The aim of this study was to determine the antibody response to influenza vaccination in children with nephrotic syndrome (NS). Nineteen children with NS and 10 healthy controls were vaccinated with a 1999-2000 influenza vaccine. A dose of 0.25 ml was used for those under 6 years and 0.5 ml for those over 6 years. All children were given two doses with a month between each dose. Antibody titers were measured before vaccination and 1 month after vaccination in both groups and 6 months after vaccination in 8 patients with NS. The proportion of subjects in the nephrotic group with protective antibody titers before immunization (10.5%) was significantly lower than the proportion at 1 (78.9%) and 6 months (87.5%) post vaccination. The mean concentration of specific IgG antibodies to influenza A in the NS group increased 6-fold at 1 month and approximately 14-fold at 6 months. These results suggest that pediatric patients with NS have an adequate antibody response to influenza A vaccine. Protective antibody titers to influenza A were maintained at 6 months after immunization in 8 patients with NS.
本研究的目的是确定肾病综合征（NS）患儿对流感疫苗的抗体反应。19名NS患儿和10名健康对照者接种了1999 - 2000年流感疫苗。6岁以下儿童接种剂量为0.25 ml，6岁以上儿童接种剂量为0.5 ml。所有儿童均接种两剂，两剂之间间隔1个月。两组均在接种前和接种后1个月测量抗体滴度，8名NS患儿还在接种后6个月测量抗体滴度。肾病组免疫前具有保护性抗体滴度的受试者比例（10.5%）显著低于接种后1个月（78.9%）和6个月（87.5%）的比例。NS组甲型流感特异性IgG抗体的平均浓度在1个月时增加了6倍，在6个月时增加了约14倍。这些结果表明，NS患儿对甲型流感疫苗有足够的抗体反应。8名NS患儿在免疫后6个月维持了对甲型流感的保护性抗体滴度。
