Cagigi Alberto, Cotugno Nicola, Rinaldi Stefano, Santilli Veronica, Rossi Paolo, Palma Paolo
University Department of Pediatrics, DPUO, Unit of Immune and Infectious Diseases, Bambino Gesù Children's Hospital, Rome, Italy.
Chair of Pediatrics, Department of System Medicine, University of Rome Tor Vergata, Rome, Italy.
Pediatr Allergy Immunol. 2016 Feb;27(1):22-7. doi: 10.1111/pai.12483. Epub 2015 Oct 20.
Response to seasonal influenza vaccination is currently evaluated by antibody correlates that estimate vaccine seroconversion as well as immune protection. These correlates rely on the general dogmas surrounding seasonal influenza vaccination; that is, that vaccine-induced antibodies would exclusively generate immunity to influenza vaccine strains and that protective immunity would wane before the next season. Here, we summarize recently reported data on immunity to seasonal influenza in healthy individuals and rediscuss results on yearly vaccinated pediatric immunocompromised patients that together highlight the need for revision of the current correlates of vaccine response to shift from quantitative to qualitative measurements.
目前，通过抗体相关性评估季节性流感疫苗的反应，这些相关性可估计疫苗血清转化以及免疫保护情况。这些相关性依赖于围绕季节性流感疫苗接种的一般信条；也就是说，疫苗诱导的抗体将专门产生针对流感疫苗株的免疫力，并且在下一个季节之前保护性免疫力会减弱。在此，我们总结了最近报道的关于健康个体对季节性流感免疫力的数据，并重新讨论了每年接种疫苗的儿科免疫功能低下患者的结果，这些结果共同凸显了修订当前疫苗反应相关性的必要性，即从定量测量转向定性测量。
