Sheth K J, Freeman M E, Eisenberg C, Sedmak G V
JAMA. 1978 Jun 16;239(24):2559-61. doi: 10.1001/jama.239.24.2559.
Before and four weeks after immunization with a single 0.5-ml dose of influenza virus vaccine, sera from 36 children with renal diseases were tested for serum hemagglutinating-inhibiting antibody (HAI) titers to A/New Jersey/76, A/Victoria/75, and A/Port Chalmers/73. Before immunization, 1:40 HI antibodies to A/New Jersey were noted in one child only, to A/Victoria in ten children (27%), and to A/Port Chalmers in 25/34 children (68%). Serum HAI titers increased fourfold or more (P less than .01) in 31/36 children (86%) after immunization. Neither the type of the renal disease nor therapy with prednisone had any effect on the rise of serum HAI titers (P less than .05). Of the seven children with preimmunization proteinuria, four had a transient rise in protein levels following immunization. None required an increased prednisone dose for exacerbation of nephrotic syndrome. Children with chronic renal problems should be protected against influenza.
在用单剂量0.5毫升流感病毒疫苗免疫前及免疫四周后，对36名患有肾脏疾病的儿童的血清进行检测，以测定其针对A/新泽西/76、A/维多利亚/75和A/查尔姆斯港/73的血清血凝抑制抗体（HAI）滴度。免疫前，仅一名儿童对A/新泽西的HI抗体为1:40，十名儿童（27%）对A/维多利亚的HI抗体为1:40，34名儿童中有25名（68%）对A/查尔姆斯港的HI抗体为1:40。免疫后，36名儿童中有31名（86%）血清HAI滴度升高四倍或更多（P小于0.01）。肾脏疾病的类型以及泼尼松治疗均对血清HAI滴度的升高无任何影响（P小于0.05）。在免疫前有蛋白尿的七名儿童中，四名儿童免疫后蛋白水平短暂升高。无人因肾病综合征加重而需要增加泼尼松剂量。患有慢性肾脏问题的儿童应预防流感。
