Vasquez S, Kavanaugh A F, Schneider N R, Wacholtz M C, Lipsky P E
Harold C. Simmons Arthritis Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
J Rheumatol. 1992 Oct;19(10):1625-7.
We describe a case of acute nonlymphocytic leukemia with inversion of chromosome 16 in a patient with systemic lupus erythematosus treated with immunosuppressive agents including azathioprine and cyclophosphamide. Although the leukemia may have been caused by other factors, it is worth noting the potential association of this malignancy with immunosuppressive therapy.
我们描述了一例患有系统性红斑狼疮的患者，在用包括硫唑嘌呤和环磷酰胺在内的免疫抑制剂治疗期间发生了伴有16号染色体倒位的急性非淋巴细胞白血病。尽管白血病可能由其他因素引起，但值得注意的是这种恶性肿瘤与免疫抑制治疗之间的潜在关联。
