Maheshwari Anu, Pandey Meenu, Rath Bimbadhar, Chandra Jagdish, Singh Smita, Sharma Sunita
Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India.
Indian J Med Paediatr Oncol. 2011 Jul;32(3):154-6. doi: 10.4103/0971-5851.92816.
The association of systemic lupus erythematosus (SLE) and myeloproliferative and lymphoproliferative malignancies is widely reported. There is scarce information available with regards to the association of SLE and malignancy in children. Usually, SLE precedes the onset of lymphoproliferative disease, but the neoplasia can occur earlier or even simultaneously. There are only five pediatric cases of SLE and associated acute lymphoblastic leukemia (ALL) reported in literature. All of these except one satisfied the revised American College of Rheumatology Criteria for SLE. Three of these cases developed SLE several years after successful treatment of ALL. While two cases reported had simultaneous onset of SLE and ALL, one of the cases in this two-patient series, did not fulfill ≥4 criteria for diagnosis of SLE. We present a case of a 3-year-old boy with SLE and coexistent ALL. To the best of our knowledge, only two such cases of simultaneous presentation of both these diseases are present in literature.
系统性红斑狼疮（SLE）与骨髓增殖性和淋巴增殖性恶性肿瘤的关联已有广泛报道。关于儿童SLE与恶性肿瘤的关联，现有信息稀少。通常，SLE先于淋巴增殖性疾病发病，但肿瘤也可能更早发生甚至同时出现。文献中仅报道了5例小儿SLE合并急性淋巴细胞白血病（ALL）的病例。除1例之外，所有这些病例均符合美国风湿病学会修订的SLE标准。其中3例在ALL成功治疗数年之后发生了SLE。虽然有2例报道SLE和ALL同时发病，但在这2例病例系列中，有1例不符合SLE诊断的≥4条标准。我们报告1例3岁男孩患SLE并合并ALL。据我们所知，文献中仅存在2例这两种疾病同时出现的病例。
