Smida Mahmoud, Nouri Hbib, Kandara Hajer, Jalel Chakib, Ben Ghachem Maher
Department of Paediatric Orthopaedics, Tunis Children's Hospital (Hôpital d'Enfants de Tunis), Bab Saadoun 1007 Tunis, Tunisia.
Acta Orthop Belg. 2003 Oct;69(5):458-62.
The authors report two cases of bone disorders in children with short stature, with confirmed growth hormone (GH) deficiency treated by GH supplementation. The first patient, aged 15 years, developed avascular necrosis of the femoral head and scoliosis. The second one, aged 17 years, had avascular necrosis of the femoral capital epiphysis on one side and acute slipped capital femoral epiphysis (SCFE) on the other side. All these complications were diagnosed while they were receiving GH-therapy. The exact aetiology and the role of GH in the pathogenesis of these conditions are still unknown.
作者报告了两例身材矮小儿童的骨骼疾病病例，这些儿童经确诊为生长激素（GH）缺乏并接受了GH补充治疗。首例患者为15岁，发生了股骨头缺血性坏死和脊柱侧弯。第二例患者为17岁，一侧发生了股骨头骨骺缺血性坏死，另一侧发生了急性股骨头骨骺滑脱（SCFE）。所有这些并发症均在他们接受GH治疗期间被诊断出来。这些病症的确切病因以及GH在其发病机制中的作用仍不清楚。
