环境烟草烟雾与成人期哮喘：一项基于人群的发病病例对照研究。
Environmental tobacco smoke and adult-onset asthma: a population-based incident case-control study.
作者信息
Jaakkola Maritta S, Piipari Ritva, Jaakkola Niina, Jaakkola Jouni J K
机构信息
Finnish Institute of Occupational Health, Helsinki, Finland.
出版信息
Am J Public Health. 2003 Dec;93(12):2055-60. doi: 10.2105/ajph.93.12.2055.
OBJECTIVES
The authors assessed the effects of environmental tobacco smoke (ETS) on the development of asthma in adults.
METHODS
In the Pirkanmaa district of South Finland, all 21- to 63-year-old adults with new cases of asthma diagnosed during a 2.5-year period (n = 521 case patients, out of 441 000 inhabitants) and a random sample of control subjects from the source population (932 control subjects) participated in a population-based incident case-control study.
RESULTS
Risk of asthma was related to workplace ETS exposure (adjusted odds ratio [OR] = 2.16; 95% confidence interval [CI] = 1.26, 3.72) and home exposure (OR = 4.77; 95% CI = 1.29, 17.7) in the past year. Cumulative ETS exposure over a lifetime at work and at home increased the risk.
CONCLUSIONS
This study indicates for the first time that both cumulative lifetime and recent ETS exposures increase the risk of adult-onset asthma.
目的
作者评估了环境烟草烟雾（ETS）对成人哮喘发病的影响。
方法
在芬兰南部的皮尔卡区，在2.5年期间确诊的所有21至63岁哮喘新发病例的成年人（在441000名居民中有521例病例患者）以及来自源人群的随机对照样本（932名对照对象）参与了一项基于人群的发病病例对照研究。
结果
在过去一年中，哮喘风险与工作场所ETS暴露（调整后的优势比[OR]=2.16；95%置信区间[CI]=1.26，3.72）和家庭暴露（OR=4.77；95%CI=1.29，17.7）有关。一生中在工作场所和家庭中的累积ETS暴露增加了风险。
结论
本研究首次表明，一生中累积的ETS暴露和近期的ETS暴露都会增加成人期哮喘的风险。
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