Peng Ai-Yun, Ding Yi-Xiang
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
J Am Chem Soc. 2003 Dec 10;125(49):15006-7. doi: 10.1021/ja038627f.
Cu(I)-catalyzed intramolecular cyclization of o-ethynylphenylphosphonic acid monoethyl esters was examined, and a new class of six-membered phosphorus heterocycles was formed with high regioselectivity and good yields. The present reaction is the first example of intramolecular addition of P-OH to alkynes, which provides a convenient way to synthesize novel phosphorus heterocycles having potential bioactivities.
研究了铜（I）催化的邻乙炔基苯基膦酸单乙酯的分子内环化反应，形成了一类新型的具有高区域选择性和良好产率的六元磷杂环。本反应是P-OH对炔烃分子内加成的首例，为合成具有潜在生物活性的新型磷杂环提供了一种便捷方法。
