接受诺氟沙星治疗的患者中，空肠弯曲菌对喹诺酮类药物的耐药性迅速出现。
Rapid emergence of quinolone resistance in Campylobacter jejuni in patients treated with norfloxacin.
作者信息
Wretlind B, Strömberg A, Ostlund L, Sjögren E, Kaijser B
机构信息
Department of Clinical Bacteriology, Danderyd Hospital, Sweden.
出版信息
Scand J Infect Dis. 1992;24(5):685-6. doi: 10.3109/00365549209054659.
15/60 subjects from one center, who all took part in a multicenter double-blind, placebo-controlled study to evaluate the effect of norfloxacin on acute enteritis, had norfloxacin sensitive strains of Campylobacter jejuni in pre-study stool specimens. Eight of the 15 subjects received active drug. In 3 of these 8, high-level quinolone resistant Campylobacter strains of the same serotype as in pre-treatment samples were isolated 4-90 days after the initiation of treatment.
来自一个中心的60名受试者中的15名，他们都参与了一项多中心双盲、安慰剂对照研究以评估诺氟沙星对急性肠炎的疗效，在研究前的粪便标本中检测出空肠弯曲菌诺氟沙星敏感菌株。这15名受试者中有8名接受了活性药物治疗。在这8名受试者中的3名中，在治疗开始后的4至90天内，分离出了与治疗前样本中相同血清型的高水平喹诺酮耐药弯曲菌菌株。
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