空肠弯曲菌中喹诺酮类高水平耐药性的快速出现与gyrA和parC的突变变化有关。
Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.
作者信息
Gibreel A, Sjögren E, Kaijser B, Wretlind B, Sköld O
机构信息
Division of Microbiology, Department of Pharmaceutical Biosciences, Biomedical Center, Uppsala University, Uppsala, Sweden.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3276-8. doi: 10.1128/AAC.42.12.3276.
Abstract
Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 microgram of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product.
摘要
20世纪90年代初，瑞典空肠弯曲菌临床分离株对喹诺酮类药物的耐药性增加了20多倍。临床分离株对每毫升125微克环丙沙星的耐药性与空肠弯曲菌的染色体突变有关，这些突变导致gyrA产物中的苏氨酸86被异亮氨酸取代，parC产物中的精氨酸139被谷氨酰胺取代。
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