Caspari P G, Newcomb M, Gibson K, Harris P
Cardiovasc Res. 1977 Nov;11(6):554-8. doi: 10.1093/cvr/11.6.554.
Estimates of the collagen concentration in human ventricles have been made from measurements of the hydroxyproline concentration. In the normal heart the concentration of collagen was higher in the right ventricle than in the left ventricle. Age had no effect on the ventricular concentration of collagen. Hypertrophy in the absence of a valvar lesion was not associated with an increased concentration of collagen but, owing to the increased size of the ventricle, there was an increase in the estimated total mass of ventricular collagen. The concentration of collagen in the left ventricle of patients with aortic stenosis was higher than normal. Ventricular hypertrophy seems to be accompanied by an increase in the total mass of collagen whatever the cause. Whether the concentration changes or not depends on the proportion in which the mass of collagen increases relative to the mass of muscle cells.
已通过测量羟脯氨酸浓度对人心脏心室中的胶原蛋白浓度进行了估算。在正常心脏中，右心室的胶原蛋白浓度高于左心室。年龄对心室胶原蛋白浓度没有影响。无瓣膜病变的心肌肥厚与胶原蛋白浓度增加无关，但由于心室大小增加，估算的心室胶原蛋白总质量有所增加。主动脉瓣狭窄患者左心室中的胶原蛋白浓度高于正常水平。无论病因如何，心室肥厚似乎都伴随着胶原蛋白总质量的增加。胶原蛋白浓度是否改变取决于胶原蛋白质量相对于肌肉细胞质量增加的比例。
