Sierksma Aafje, Lebrun Corinne E I, van der Schouw Yvonne T, Grobbee Diederick E, Lamberts Steven W J, Hendriks Henk F J, Bots Michiel L
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):342-8. doi: 10.1161/01.ATV.0000110784.52412.8f. Epub 2003 Dec 4.
Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections.
Three hundred seventy-one healthy postmenopausal women aged 50 to 74 years were sampled from a population-based study. Alcohol intake was calculated from a standardized questionnaire. Applanation tonometry was applied to assess the augmentation index and aortic pulse-wave velocity. Those drinking 1 to 3, 4 to 9, 10 to 14, and 15 to 35 glasses of alcoholic beverages per week had a 0.044 (95% CI -0.47 to 0.56), -0.085 (95% CI -0.59 to 0.43), -0.869 (95% CI -1.44 to -0.29), and -0.225 (95% CI -0.98 to 0.53) m/s difference in mean pulse-wave velocity compared with nondrinkers, respectively, which indicates a J-shaped relationship. Adjustment for potential confounders of pulse-wave velocity or alcohol intake did not materially change the strength of the association. Adjustment for HDL further attenuated the relationship. The augmentation index was not related to alcohol consumption when adjustments were made for physiological determinants such as age, height, and ejection duration.
Among postmenopausal women, alcohol consumption is inversely associated with pulse-wave velocity. This supports the presence of a decreased risk of cardiovascular disease with moderate alcohol consumption, which may be mediated in part by HDL cholesterol.
据推测，适度饮酒对心脏有保护作用。这种作用可能体现在大动脉特性上，如动脉僵硬度和波反射。
从一项基于人群的研究中抽取了371名年龄在50至74岁之间的健康绝经后女性。通过标准化问卷计算酒精摄入量。采用压平式眼压计评估增强指数和主动脉脉搏波速度。与不饮酒者相比，每周饮用1至3杯、4至9杯、10至14杯和15至35杯酒精饮料的女性平均脉搏波速度分别有0.044（95%可信区间-0.47至0.56）、-0.085（95%可信区间-0.59至0.43）、-0.869（95%可信区间-1.44至-0.29）和-0.225（95%可信区间-0.98至0.53）m/s的差异，这表明呈J形关系。对脉搏波速度或酒精摄入量的潜在混杂因素进行调整并没有实质性改变关联强度。对高密度脂蛋白（HDL）进行调整进一步减弱了这种关系。在对年龄、身高和射血持续时间等生理决定因素进行调整后，增强指数与酒精摄入量无关。
在绝经后女性中，酒精摄入量与脉搏波速度呈负相关。这支持适度饮酒可降低心血管疾病风险，这可能部分由HDL胆固醇介导。
