Department of Cardiology, Tokyo Medical University.
Department of Nursing, Kiryu University.
J Atheroscler Thromb. 2023 Feb 1;30(2):192-202. doi: 10.5551/jat.63544. Epub 2022 Apr 28.
This prospective observational study, which utilized repeated annual measurements performed over a 9-year period, applied mixed model analyses to examine age-related differences in longitudinal associations between alcohol intake and arterial stiffness, pressure wave reflection, and inflammation.
In 4016 middle-aged (43±9 years) healthy Japanese male employees, alcohol intake, brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), and serum C-reactive protein (CRP) levels were measured annually during a 9-year study period.
The estimated marginal mean baPWV (non-drinkers=1306 cm/s, mild-moderate drinkers=1311 cm/s, and heavy drinkers=1337 cm/s, P＜0.01) and that of rAI showed significant stepped increases in an alcohol dose-dependent manner in the entire cohort, but an increase in rAI was not observed in subjects aged ≥ 50 years. The estimated slope of the annual increase in baPWV, but not rAI, was higher for heavy drinkers than for non-drinkers (slope difference, 1.84; P＜0.05), especially for subjects aged ＜50 years (slope difference, 2.84; P＜0.05).
In middle-aged male Japanese employees, alcohol intake may attenuate inflammatory activity. While alcohol intake may exacerbate the progression of arterial stiffening in a dose-dependent manner without mediating inflammation, especially in subjects under 50 years of age, it may promote pressure wave reflection abnormalities with aging at earlier ages without further exacerbation at older ages.
本前瞻性观察研究利用 9 年期间的年度重复测量，采用混合模型分析，考察了饮酒与动脉僵硬、压力波反射和炎症之间的纵向关联随年龄的变化差异。
在 4016 名中年（43±9 岁）健康日本男性员工中，在 9 年的研究期间内每年测量饮酒量、肱踝脉搏波速度（baPWV）、桡动脉增强指数（rAI）和血清 C 反应蛋白（CRP）水平。
在整个队列中，估计的边缘均数 baPWV（不饮酒者=1306cm/s，轻度至中度饮酒者=1311cm/s，重度饮酒者=1337cm/s，P＜0.01）和 rAI 呈剂量依赖性的阶梯式增加。但在≥50 岁的人群中，rAI 没有增加。与不饮酒者相比，重度饮酒者的 baPWV 年增长率（斜率差异为 1.84；P＜0.05），特别是＜50 岁的人群（斜率差异为 2.84；P＜0.05），斜率更高。
在中年日本男性员工中，饮酒可能会减弱炎症活动。尽管饮酒可能会以剂量依赖的方式加重动脉僵硬的进展而不介导炎症，但在年龄＜50 岁的人群中尤其如此，它可能会在年龄较小的时候促进压力波反射异常而不会在年龄较大的时候进一步恶化。
