Metz-Boutigue M H, Kieffer A E, Goumon Y, Aunis D
Unité Inserm U 575 "Physiopathologie du Système Nerveux", IFR 37, 5 rue Blaise Pascal, 67084 Cedex, Strasbourg, France.
Trends Microbiol. 2003 Dec;11(12):585-92. doi: 10.1016/j.tim.2003.10.001.
Secretory granules of chromaffin cells from the adrenal medulla store catecholamines and a variety of peptides that are secreted in the extracellular medium during exocytosis. Among these fragments, several natural peptides displaying antimicrobial activities at the micromolar range have been isolated and characterized. We have shown that these peptides, derived from the natural processing of chromogranins (CGs), proenkephalin-A (PEA) and free ubiquitin (Ub), are released into the circulation and display antibacterial and antifungal activities. In this review we focus on three naturally secreted antimicrobial peptides corresponding to CGA1-76 (vasostatin-I), the bisphosphorylated form of PEA209-237 (enkelytin) and Ub. In addition, the antimicrobial properties of the synthetic active domains of vasostatin-I (CGA47-66 or chromofungin) and Ub (Ub65-76 or ubifungin) are reported.
肾上腺髓质嗜铬细胞的分泌颗粒储存儿茶酚胺和多种肽，这些物质在胞吐过程中分泌到细胞外介质中。在这些片段中，已经分离并鉴定了几种在微摩尔范围内具有抗菌活性的天然肽。我们已经表明，这些肽源自嗜铬粒蛋白（CGs）、前脑啡肽原A（PEA）和游离泛素（Ub）的天然加工过程，它们被释放到循环系统中，并具有抗菌和抗真菌活性。在这篇综述中，我们重点关注三种天然分泌的抗菌肽，分别对应于CGA1-76（血管抑素-I）、双磷酸化形式的PEA209-237（脑啡肽素）和Ub。此外，还报道了血管抑素-I（CGA47-66或嗜铬菌素）和Ub（Ub65-76或泛菌素）的合成活性结构域的抗菌特性。
