Department of Pathology and Laboratory Medicine, University of Tennessee, Memphis, Tennessee, USA; Division of Rheumatology, Department of Medicine, Health Science Center, University of Tennessee, Memphis, Tennessee, USA.
J Invest Dermatol. 2015 Feb;135(2):333-334. doi: 10.1038/jid.2014.458.
The presence of functional opioid receptors on epidermal keratinocytes, with attendant regulation of keratinocyte proliferation and differentiation, indicates their novel role in maintaining epidermal homeostasis. Expression of proenkephalin precursors and neuropeptide products in the same compartment opens an opportunity for studying the role of this endogenous opioid circuitry, with its regulators, in modulating epidermal barrier function.
表皮角质形成细胞存在功能性阿片受体,伴随角质形成细胞增殖和分化的调节,表明其在维持表皮内稳态方面具有新的作用。脑啡肽前体和神经肽产物在同一部位的表达为研究内源性阿片电路及其调节剂在调节表皮屏障功能中的作用提供了机会。