Mast T C, Kigozi G, Wabwire-Mangen F, Black R, Sewankambo N, Serwadda D, Gray R, Wawer M, Wu A W
Department of International Health, Johns Hopkins University, Bloomberg School of Public Health, MD, Baltimore, USA.
AIDS Care. 2004 Jan;16(1):81-94. doi: 10.1080/09540120310001633994.
To examine self-reported quality of life and health status of HIV-infected women and a comparison sample of HIV-uninfected women in rural Uganda, we culturally adapted a Lugandan version of the Medical Outcomes Survey-HIV (MOS-HIV). We administered a cross-sectional survey among 803 women (239 HIV-positive and 564 HIV-negative) enrolled in a community study to evaluate maternal and child health in Rakai District, Uganda. The interview took 20 minutes and was generally well-accepted. Reliability coefficients were >0.70, except for role functioning, energy and cognitive function. MOS-HIV scores for HIV-positive women were correlated with increasing number of physical symptoms and higher HIV viral load. Compared to HIV-negative women, HIV-positive women reported lower scores than HIV-negative women for general health perceptions, physical functioning, pain, energy, role functioning, social functioning, mental health and overall quality of life (p all <0.01). Substantial impairment was noted among women reporting >/=4 symptoms. In summary, HIV-positive women reported significantly poorer functioning and well-being than HIV-negative women. We conclude that patient-reported measures of health status and related concepts may provide a feasible, reliable and valid method to assess the impact of HIV/AIDS and future therapeutic interventions to improve patient outcomes in rural Africa.
为了调查乌干达农村地区感染艾滋病毒妇女以及未感染艾滋病毒妇女对照样本的自我报告生活质量和健康状况，我们对卢干达语版的《医疗结果调查-艾滋病毒》（MOS-HIV）进行了文化适应性调整。我们对参与乌干达拉凯区一项评估母婴健康的社区研究的803名妇女（239名艾滋病毒阳性和564名艾滋病毒阴性）进行了横断面调查。访谈用时20分钟，总体上被广泛接受。除角色功能、精力和认知功能外，信度系数均>0.70。艾滋病毒阳性妇女的MOS-HIV评分与身体症状数量增加和艾滋病毒病毒载量升高相关。与艾滋病毒阴性妇女相比，艾滋病毒阳性妇女在总体健康认知、身体功能、疼痛、精力、角色功能、社会功能、心理健康和总体生活质量方面的得分低于艾滋病毒阴性妇女（所有p值均<0.01）。报告有≥4种症状的妇女存在明显损害。总之，艾滋病毒阳性妇女报告的功能和幸福感明显低于艾滋病毒阴性妇女。我们得出结论，患者报告的健康状况及相关概念的测量方法可能为评估艾滋病毒/艾滋病的影响以及未来改善非洲农村地区患者预后的治疗干预措施提供一种可行、可靠且有效的方法。
