Hooper-van Veen Tineke, Schrijver Hans M, Zwiers Antoon, Crusius J Bart A, Knol Dirk L, Kalkers Nynke F, Laine Marja L, Barkhof Frederik, Peña A Salvador, Polman Chris H, Uitdehaag Bernard M J
Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands.
Mult Scler. 2003 Dec;9(6):535-9. doi: 10.1191/1352458503ms974oa.
Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our patient population (492 MS patients and 228 controls). In the present study, we investigated the role of the IL-IA--889, IL-1B--511, IL-1B f3953 and IL-1RN VNTR gene polymorphisms in MS. In addition, we performed preliminary analyses on longitudinal magnetic resonance imaging (MRI) data. We found no associations between the polymorphisms and susceptibility to MS or clinical features. In addition, we observed no significant effect of the polymorphisms on brain or lesion volumes, Based on our data and those from the literature, one can conclude that there is currently no evidence to support a role for the IL-1 genes in MS.
多发性硬化症（MS）是一种推测源于自身免疫、受多基因显著影响的慢性疾病。我们之前观察到白细胞介素-1（IL-1）家族基因中的特定等位基因组合会影响MS的进展速度。我们大幅扩大了患者群体（492例MS患者和228例对照）。在本研究中，我们调查了IL-1A -889、IL-1B -511、IL-1B f3953和IL-1RN VNTR基因多态性在MS中的作用。此外，我们对纵向磁共振成像（MRI）数据进行了初步分析。我们未发现这些多态性与MS易感性或临床特征之间存在关联。此外，我们未观察到这些多态性对脑容量或病灶体积有显著影响。根据我们的数据以及文献中的数据，可以得出结论，目前没有证据支持IL-1基因在MS中起作用。
