Ehde Dawn M, Gibbons Laura E, Chwastiak Lydia, Bombardier Charles H, Sullivan Mark D, Kraft George H
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA.
Mult Scler. 2003 Dec;9(6):605-11. doi: 10.1191/1352458503ms939oa.
This study examined the prevalence, intensity, interference, and biopsychosocial correlates of pain in a large community-based sample of persons with multiple sclerosis (MS).
Mail surveys were returned by 442 members of the King County (WA) MS Association. Average pain intensity, pain-related activity interference, depressive symptoms and severity of MS were assessed.
Forty-four percent reported persistent, bothersome pain in the three months prior to completing the survey. Participants with pain reported an average pain intensity rating of 5.2 (SD = 2.3) on the 0 (no pain) to 10 (pain as bad as could be) scale. Twenty-seven percent reported severe pain (score of 7-10), while 51% of those with pain rated the interference of their pain with daily activities as none to minimal. Twenty percent reported severe interference in activities as a result of pain. In multivariate modeling, MS illness severity, marital status, and self-ratings of overall health were significantly associated with pain-related interference with activities.
Approximately a fourth of this sample described having a chronic pain problem characterized by severe pain intensity and significant pain-related interference with activities. Disability due to pain may be more important than previously recognized for the MS population.
本研究调查了一个基于社区的大型多发性硬化症（MS）患者样本中疼痛的患病率、强度、干扰以及生物心理社会相关因素。
华盛顿州金县MS协会的442名成员回复了邮寄调查问卷。评估了平均疼痛强度、疼痛相关的活动干扰、抑郁症状以及MS的严重程度。
44%的受访者报告在完成调查前的三个月内存在持续的、令人烦恼的疼痛。有疼痛的参与者在0（无疼痛）至10（疼痛至极）的量表上报告的平均疼痛强度评分为5.2（标准差 = 2.3）。27%的受访者报告有严重疼痛（评分7 - 10），而51%有疼痛的受访者将疼痛对日常活动的干扰评为无至最小。20%的受访者报告疼痛对活动有严重干扰。在多变量模型中，MS疾病严重程度、婚姻状况以及整体健康的自我评分与疼痛相关的活动干扰显著相关。
该样本中约四分之一的人描述存在慢性疼痛问题，其特征为严重的疼痛强度以及与活动相关的显著疼痛干扰。对于MS人群，疼痛导致的残疾可能比之前认识到的更为重要。
