Bawden J W, Deaton T G, Koch G G, Crawford B P
Department of Pediatric Dentistry, University of North Carolina, Chapel Hill 27599-7455.
Arch Oral Biol. 1992 Nov;37(11):929-33. doi: 10.1016/0003-9969(92)90064-f.
This study was designed to explore various aspects of maternal-fetal fluoride metabolism. In its first phase, 57 female guinea pigs were bred and randomly assigned to a control group (I) or one of three experimental groups: (II) 3 parts/10(6) fluoride in drinking water, (III) a single daily oral dose and (IV) 3 parts/10(6) fluoride in water and a single daily oral fluoride dose. The total mean doses received by groups II and III were similar. The total mean dose received by group IV was approximately double that for groups II and III. Samples of maternal plasma, and fetal bone and enamel were collected on the 57th day of gestation. In its second phase, 53 pregnant guinea pigs were given drinking water containing 0, 2, 4, 6 or 8 parts/10(6) fluoride during gestation. On the 57th day of gestation samples of maternal and fetal enamel were collected. All samples in both phases of the study were assayed for fluoride using the microdiffusion, ion-selective electrode method. In the first part of the study, mean fetal enamel fluoride by group was: I, 21.6 parts/10(6); II, 38.6 parts/10(6); III, 33.5 parts/10(6); IV, 54.9 parts/10(6). In the second phase, maternal enamel was linearly related to the fluoride dose. The same was true for fetal enamel except at the 8 parts/10(6) fluoride level in the water where there was no increase over the 6 parts/10(6) group. At all dose levels, fetal enamel fluoride uptake was approximately an order of magnitude less than maternal enamel fluoride uptake.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究旨在探讨母胎氟代谢的各个方面。在第一阶段，繁殖了57只雌性豚鼠，并将它们随机分为一个对照组（I）或三个实验组之一：（II）饮用水中含氟量为3/10⁶，（III）每日单次口服剂量，以及（IV）饮用水中含氟量为3/10⁶且每日单次口服氟剂量。第二组和第三组接受的总平均剂量相似。第四组接受的总平均剂量约为第二组和第三组的两倍。在妊娠第57天采集母体血浆、胎儿骨骼和牙釉质样本。在第二阶段，53只怀孕豚鼠在妊娠期间饮用含0、2、4、6或8/10⁶氟的水。在妊娠第57天采集母体和胎儿牙釉质样本。研究两个阶段的所有样本均采用微扩散离子选择电极法测定氟含量。在研究的第一部分，各实验组胎儿牙釉质平均含氟量为：I组，21.6/10⁶；II组，38.6/10⁶；III组，33.5/10⁶；IV组，54.9/10⁶。在第二阶段，母体牙釉质含氟量与氟剂量呈线性相关。胎儿牙釉质也是如此，但水中氟含量为8/10⁶时除外，该组胎儿牙釉质含氟量与6/10⁶组相比没有增加。在所有剂量水平下，胎儿牙釉质对氟的摄取量比母体牙釉质对氟的摄取量大约低一个数量级。（摘要截短于250字）
