Jelsma Jennifer, Mkoka Siviwe, Amosun Ladele, Nieuwveldt Judith
Division of Physiotherapy, School of Health and Rehabilitation Sciences, University of Cape Town, South Africa.
Disabil Rehabil. 2004 Jan 21;26(2):103-8. doi: 10.1080/09638280310001629705.
This study aimed to examine the reliability and validity of the Xhosa version of the EQ-5D, a Health Related Quality of Life measure which is often used as an outcome measure in clinical trials, within an urban Xhosa speaking population.
The test-retest reliability was examined on a community and institutional sample of 88 subjects, who were interviewed twice, one week apart. Forty-nine out- and in-patients participated in the second part of the study, in which the concurrent validity of the EQ-5D against existing Xhosa measures of similar domains as the EQ-5D was examined.
The Intraclass correlation (ICC) co-efficients between the first and second interviews ranged from 0.39 to 0.75 in different domains. The ICC for the Visual Analogue Scale of health state was 0.63. In the validity study, those who reported no problems with mobility demonstrated a significantly higher gait velocity. There was a significant difference between the rank ordering of scores on the four domains of self-care, usual activities pain/discomfort and anxiety/depression and the scores obtained on the 'gold standard' tests.
It is concluded that, although some domains might need to be examined further, the Xhosa EQ-5D is a valid and reliable instrument with which to determine HRQoL in an urban Xhosa speaking population. In order to ensure validity of results in multicultural research and drug trials, it is essential that more outcome measures are subjected to rigorous translation and testing of validity and reliability.
本研究旨在检验科萨语版EQ-5D的信度和效度。EQ-5D是一种与健康相关的生活质量测量工具，常用于临床试验的结果测量，此次研究对象为城市中讲科萨语的人群。
在88名受试者的社区和机构样本中检验了重测信度，这些受试者接受了两次访谈，间隔一周。49名门诊和住院患者参与了研究的第二部分，该部分检验了EQ-5D与科萨语中与EQ-5D类似领域的现有测量工具的同时效度。
在不同领域，第一次和第二次访谈之间的组内相关系数（ICC）在0.39至0.75之间。健康状态视觉模拟量表的ICC为0.63。在效度研究中，那些报告行动能力无问题的人表现出明显更高的步态速度。在自我护理、日常活动、疼痛/不适和焦虑/抑郁这四个领域的得分排序与“金标准”测试获得的分数之间存在显著差异。
得出的结论是，尽管某些领域可能需要进一步研究，但科萨语版EQ-5D是一种有效且可靠的工具，可用于确定城市中讲科萨语人群的健康相关生活质量。为了确保多元文化研究和药物试验结果的有效性，必须对更多的结果测量工具进行严格的翻译以及效度和信度测试。
