Grau-Serrat Victor, Carr Catherine E, Simon Jonathan Z
Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
Biol Cybern. 2003 Nov;89(5):388-96. doi: 10.1007/s00422-003-0444-4. Epub 2003 Nov 28.
A biologically detailed model of the binaural avian nucleus laminaris is constructed, as a two-dimensional array of multicompartment, conductance-based neurons, along tonotopic and interaural time delay (ITD) axes. The model is based primarily on data from chick nucleus laminaris. Typical chick-like parameters perform ITD discrimination up to 2 kHz, and enhancements for barn owl perform ITD discrimination up to 6 kHz. The dendritic length gradient of NL is explained concisely. The response to binaural out-of-phase input is suppressed well below the response to monaural input (without any spontaneous activity on the opposite side), implicating active potassium channels as crucial to good ITD discrimination.
构建了一个双耳禽层状核的生物细节模型，该模型作为一个基于电导的多隔室神经元的二维阵列，沿着音频拓扑和双耳时间延迟（ITD）轴排列。该模型主要基于来自鸡层状核的数据。典型的类似鸡的参数可实现高达2 kHz的ITD辨别，而谷仓猫头鹰的增强参数可实现高达6 kHz的ITD辨别。简明地解释了层状核的树突长度梯度。对双耳异相输入的反应被抑制到远低于对单耳输入的反应（另一侧没有任何自发活动），这表明活性钾通道对良好的ITD辨别至关重要。
