Ashida Go, Funabiki Kazuo, Kretzberg Jutta
Cluster of Excellence "Hearing4all", Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Systems Biology, Osaka Bioscience Institute, Suita, Osaka, Japan.
PLoS One. 2015 Apr 6;10(4):e0122796. doi: 10.1371/journal.pone.0122796. eCollection 2015.
Sound localization is a fundamental sensory function of a wide variety of animals. The interaural time difference (ITD), an important cue for sound localization, is computed in the auditory brainstem. In our previous modeling study, we introduced a two-compartment Hodgkin-Huxley type model to investigate how cellular and synaptic specializations may contribute to precise ITD computation of the barn owl's auditory coincidence detector neuron. Although our model successfully reproduced fundamental physiological properties observed in vivo, it was unsuitable for mathematical analyses and large scale simulations because of a number of nonlinear variables. In the present study, we reduce our former model into three types of conductance-based integrate-and-fire (IF) models. We test their electrophysiological properties using data from published in vivo and in vitro studies. Their robustness to parameter changes and computational efficiencies are also examined. Our numerical results suggest that the single-compartment active IF model is superior to other reduced models in terms of physiological reproducibility and computational performance. This model will allow future theoretical studies that use more rigorous mathematical analysis and network simulations.
声音定位是多种动物的一项基本感觉功能。双耳时间差（ITD）是声音定位的一个重要线索，它在听觉脑干中进行计算。在我们之前的建模研究中，我们引入了一个双室霍奇金-赫胥黎型模型，以研究细胞和突触特化如何有助于仓鸮听觉重合检测神经元精确计算ITD。尽管我们的模型成功地再现了体内观察到的基本生理特性，但由于存在许多非线性变量，它不适合进行数学分析和大规模模拟。在本研究中，我们将之前的模型简化为三种基于电导的积分发放（IF）模型。我们使用已发表的体内和体外研究数据来测试它们的电生理特性。还检查了它们对参数变化的鲁棒性和计算效率。我们的数值结果表明，单室有源IF模型在生理再现性和计算性能方面优于其他简化模型。该模型将为未来使用更严格数学分析和网络模拟的理论研究提供可能。
