Biernat Inga, Szczudrawa Andrzej, Tomaszczyk Józef, Ludwin Artur
Katedry Ginekologii i Połoznictwa, Kliniki Ginekologii, Połoznictwa i Onkologii CM UJ w Krakowie.
Ginekol Pol. 2003 Oct;74(10):1066-9.
Evaluation of incidence of HPV infection in pregnant women.
Material consisted of 145 pregnant patients with a range age from 18 to 37, in 2nd or 3d trimester of pregnancy. The control-group included non-pregnant women, participants of preventive skinning programme against cervical cancer, as number and age structure as the study group. All patients had cervical specimens collected for cytological evaluation. Specimens for HPV testing were taken by Digene Sampler Cervical Kit--from cervix and posterior fornix. The presence of HPV DNA was detected with the Hybrid Capture II, dividing into 2 groups of high and low risk cancer associated types.
DNA HPV was detected in 19 (13.1%) pregnant women treated in Department of Obstetrics, Gynaecology and Oncology. In 14 (9.6%) non-pregnant women from control group the Hybrid Capture II test was positive. The difference in frequency of infection has not statistical significance (Chi 2 = 0.55 alpha = 0.05). Respectively in 11(7.6%) and 8(5.5%) patients from I group HPV of high and low risk cancer associated type were detected. In II group infection of viruses with high risk was detected in 8 (5.5%), and with low cancer risk in 6(4.1%) patients. As I group as II group the presence of DNA HPV was estimated in younger women.
The pregnancy does not seem to be independent factor that increases frequency of HPV infections. Despite of changes in hormonal balance and associated with pregnancy increase of immunity we have not found statistical significant differences between the study-group and control-group. There seem to be in connection with changes of sexual behaviour of pregnant women.
评估孕妇人乳头瘤病毒（HPV）感染率。
材料包括145例年龄在18至37岁之间、处于妊娠中期或晚期的孕妇。对照组包括非孕妇，她们是宫颈癌预防筛查项目的参与者，人数和年龄结构与研究组相同。所有患者均采集宫颈标本进行细胞学评估。HPV检测标本采用Digene宫颈采样试剂盒从宫颈和后穹窿采集。采用第二代杂交捕获法检测HPV DNA，分为高危型和低危型两组。
在妇产科与肿瘤科接受治疗的19例（13.1%）孕妇中检测到HPV DNA。对照组14例（9.6%）非孕妇的第二代杂交捕获试验呈阳性。感染频率的差异无统计学意义（卡方检验=0.55，α=0.05）。第一组分别有11例（7.6%）和8例（5.5%）患者检测到高危型和低危型HPV。第二组有8例（5.5%）患者检测到高危型病毒感染，6例（4.1%）患者检测到低危型病毒感染。第一组和第二组中，较年轻女性中均检测到HPV DNA。
妊娠似乎不是增加HPV感染频率的独立因素。尽管激素平衡发生变化且妊娠相关免疫力增强，但我们未发现研究组与对照组之间存在统计学显著差异。这似乎与孕妇性行为的改变有关。
