Tarka Agata, Szczepańska Małgorzata, Rokita Wojciech, Józefiak Agata, Kedzia Witold
Wydział Nauk o Zdrowiu, Uniwersytet Medyczny w Poznaniu, Polska.
Ginekol Pol. 2011 Sep;82(9):664-9.
One of the potential ways of HPV transmission to fetuses and newborns is a direct perinatal infection, manifested as juvenile laryngeal papillomatosis (JLP). This applies to children after traditional birth, born to mothers in whom the DNA sequences of the HPV HR in the paraepidermal epithelium of cervix were found during pregnancy and delivery
Risk assessment of the development of chronic HPV HR infection in babies who had contact with the virus in the perinatal period.
During the pre- and perinatal period, research was carried out among 185 pregnant women and a group of 105 newborns (5 pairs of twins), hospitalized in the Delivery Room of the Gynecology and Obstetrics Clinic of the Poznań Medical University between 2005-2007. Cellular material from the uterine cervical canal using a brush-type Cervex Brush was collected from each woman participating in the study and oral swabs using swab sticks were taken from the newborns. The second phase of testing was conducted following the postpartum, 3 to 6 months after the delivery Uterine cervix swabs were re-collected from 28 HPV HR positive women and swab from the mouth and nasopharynx were taken from their children (29 samples--1 pair of twins). The study was conducted with the use of PCR, trade named AMPLICOR Human Papilloma Virus (HPV) Test by Roche.
DNA HPV HR was found in 55 cases of the cellular material derived from 185 swabs taken from the cervical canal, representing 29.7% of researched women. The chronic HPV HR viral infection was detected in 25 cases out of the 28 HPV HR positive women, representing 89.2% of the study group. Of the 105 infants from whom oral swabs were taken in the perinatal period, presence of DNA HPV HR was found in 2 infants (2%) after traditional birth. Whereas the repeated test, within 3-6 months after delivery revealed the presence of DNA HPV HR viruses in swab oral in 1 infant, who had been DNA HPV HR positive.
Perinatal transmission of Human Papillomavirus of the high-risk oncogenic type is rare and concerns below 2% of babies of HPV HR positive mothers. Prolonged infection by the Human Papillomavirus is an extremely rare complication of pregnancy and delivery and concerns below 1% of children of HPV HR positive mothers. Perinatal transmission of the oncogenic type infection of the virus in humans is primarily of the ascending type or occurs during the perinatal period if the delivery was a traditional one.
人乳头瘤病毒（HPV）传播给胎儿和新生儿的一种潜在途径是直接围产期感染，表现为青少年喉乳头状瘤病（JLP）。这适用于顺产的儿童，其母亲在孕期和分娩时宫颈表皮下上皮细胞中发现了HPV高危型（HR）的DNA序列。
评估围产期接触该病毒的婴儿发生慢性HPV HR感染的风险。
在2005年至2007年期间，对波兹南医科大学妇产科诊所产房收治的185名孕妇和105名新生儿（5对双胞胎）进行了围产期前后的研究。使用宫颈刷从参与研究的每位女性的子宫颈管采集细胞样本，用棉签从新生儿口腔采集样本。产后3至6个月进行了第二阶段检测，从28名HPV HR阳性女性中再次采集宫颈拭子，并从其子女（29个样本，1对双胞胎）的口腔和鼻咽部采集样本。该研究使用了罗氏公司生产的名为AMPLICOR人乳头瘤病毒（HPV）检测的聚合酶链反应（PCR）技术。
在从185名女性宫颈管采集的样本中，有55例检测到HPV HR DNA，占研究女性的29.7%。在28名HPV HR阳性女性中，有25例检测到慢性HPV HR病毒感染，占研究组的89.2%。在围产期采集口腔样本的105名婴儿中，顺产的2名婴儿（2%）检测到HPV HR DNA。而产后3至6个月的重复检测显示，1名HPV HR DNA阳性母亲的婴儿口腔拭子中检测到HPV HR病毒。
高危致癌型人乳头瘤病毒的围产期传播很少见，HPV HR阳性母亲的婴儿中感染率低于2%。人乳头瘤病毒的长期感染是妊娠和分娩极其罕见的并发症，并在HPV HR阳性母亲的子女中发生率低于1%。人类病毒致癌型感染的围产期传播主要是上行性的，或者在顺产时发生在围产期。
