Pasquina Patrick, Tramèr Martin R, Walder Bernhard
Division of Surgical Intensive Care, Department of Anaesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospitals, Switzerland.
BMJ. 2003 Dec 13;327(7428):1379. doi: 10.1136/bmj.327.7428.1379.
To assess whether respiratory physiotherapy prevents pulmonary complications after cardiac surgery.
Searches through Medline, Embase, Cinahl, the Cochrane library, and bibliographies, for randomised trials comparing any type of prophylactic respiratory physiotherapy with another type or no intervention after cardiac surgery, with a follow up of at least two days, and reporting on respiratory outcomes.
Investigators assessed trial validity independently. Information on study design, population, interventions, and end points was abstracted by one investigator and checked by the others.
18 trials (1457 patients) were identified. Most were of low quality. They tested physical therapy (13 trials), incentive spirometry (eight), continuous positive airway pressure (five), and intermittent positive pressure breathing (three). The maximum follow up was six days. Four trials only had a no intervention control; none showed any significant benefit of physiotherapy. Across all trials and interventions, average values postoperatively were: incidence of atelectasis, 15-98%; incidence of pneumonia, 0-20%; partial pressure of arterial oxygen per inspired oxygen fraction, 212-329 mm Hg; vital capacity, 37-72% of preoperative values; and forced expiratory volume in one second, 34-72%. No intervention showed superiority for any end point. For the most labour intensive intervention, continuous positive airway pressure, the average cost of labour for each patient day was 27 euro (pound 19; 32 dollars).
The usefulness of respiratory physiotherapy for the prevention of pulmonary complications after cardiac surgery remains unproved. Large randomised trials are needed with no intervention controls, clinically relevant end points, and reasonable follow up periods.
评估呼吸物理治疗能否预防心脏手术后的肺部并发症。
通过检索医学期刊数据库(Medline)、荷兰医学文摘数据库(Embase)、护理学与健康领域数据库(Cinahl)、考克兰图书馆以及参考文献,查找比较心脏手术后任何类型的预防性呼吸物理治疗与其他类型治疗或不干预措施的随机试验,随访时间至少为两天,并报告呼吸相关结局。
研究人员独立评估试验的有效性。一名研究人员提取有关研究设计、研究对象、干预措施和终点的信息,其他人员进行核对。
共识别出18项试验(1457例患者)。大多数试验质量较低。试验涉及物理治疗(13项试验)、激励式肺量计(8项)、持续气道正压通气(5项)和间歇正压通气(3项)。最长随访时间为6天。只有4项试验设有不干预对照组;均未显示物理治疗有任何显著益处。在所有试验和干预措施中,术后平均值如下:肺不张发生率为15% - 98%;肺炎发生率为0% - 20%;动脉血氧分压与吸入氧分数之比为212 - 329 mmHg;肺活量为术前值的37% - 72%;第一秒用力呼气量为术前值的34% - 72%。没有任何干预措施在任何终点上显示出优越性。对于最耗费人力的干预措施持续气道正压通气,每位患者每天的平均人工成本为27欧元(19英镑;32美元)。
呼吸物理治疗对预防心脏手术后肺部并发症的有效性尚未得到证实。需要进行大规模的随机试验,设立不干预对照组、具有临床相关性的终点以及合理的随访期。