Neumann Charlotte G, Bwibo Nimrod O, Murphy Suzanne P, Sigman Marian, Whaley Shannon, Allen Lindsay H, Guthrie Donald, Weiss Robert E, Demment Montague W
Department of Community Health Sciences and Pediatrics, Schools of Public Health and Medicine, University of California, Los Angeles, CA, USA.
J Nutr. 2003 Nov;133(11 Suppl 2):3941S-3949S. doi: 10.1093/jn/133.11.3941S.
A previous longitudinal three-country study in Egypt, Kenya and Mexico found significant positive associations between intake of animal source foods (ASF) and growth, cognitive development and physical activity. To test for a causal relationship, a controlled school feeding intervention study was designed to test the hypotheses that ASF would improve micronutrient status, growth and cognitive function in Kenyan primary school children. Twelve rural Kenyan schools with 554 children were randomized to four feeding interventions using a local vegetable stew as the vehicle. The groups were designated as Meat, Milk, Energy and Control, who received no feedings. Feeding was carried out on school days for seven terms during 21 mo. Preintervention baseline measures included nutritional status, home food intake, anthropometry, biochemical measures of micronutrient status, malaria, intestinal parasites, health status and cognitive and behavioral measures. The measurements of each child were repeated at intervals over 2 y. Baseline data revealed stunting and underweight in approximately 30% of children and widespread inadequate intakes and/or biochemical evidence of micronutrient deficiencies, particularly of iron, zinc, vitamins A and B-12, riboflavin and calcium. Little or no ASF were eaten and fat intake was low. Malaria was present in 31% of children, and hookworm, amebiasis and giardia were widely prevalent. The outcomes measured were rates of change or increase during the intervention in cognitive function, growth, physical activity and behavior and micronutrient status. Hierarchical linear random effects modeling was used for analysis of outcomes.
此前在埃及、肯尼亚和墨西哥开展的一项三国纵向研究发现,动物源食物(ASF)的摄入量与生长发育、认知发展及身体活动之间存在显著的正相关关系。为了检验因果关系,设计了一项对照学校供餐干预研究,以验证以下假设:ASF能够改善肯尼亚小学生的微量营养素状况、生长发育及认知功能。肯尼亚农村地区的12所学校的554名儿童被随机分为四组,采用当地蔬菜炖菜作为载体进行四种供餐干预。这四组分别为肉类组、奶类组、能量组和对照组(不接受供餐)。在21个月内的上学日进行了七个学期的供餐。干预前的基线测量包括营养状况、家庭食物摄入量、人体测量、微量营养素状况的生化指标、疟疾、肠道寄生虫、健康状况以及认知和行为指标。每隔2年对每个儿童的测量数据进行重复。基线数据显示,约30%的儿童存在发育迟缓及体重不足的情况,微量营养素缺乏普遍存在,摄入量不足和/或有生化指标证明,尤其是铁、锌、维生素A、维生素B - 12、核黄素和钙。几乎不吃或很少吃ASF,脂肪摄入量较低。31%的儿童感染疟疾,钩虫、阿米巴病和贾第虫病广泛流行。所测量的结果是干预期间认知功能、生长发育、身体活动和行为以及微量营养素状况的变化率或增加情况。采用分层线性随机效应模型对结果进行分析。