同种致敏人T细胞介导的抗体依赖性细胞毒性作用。
Antibody-dependent cellular cytotoxicity by allosensitized human T cells.
作者信息
Evans R L, Chess L, Levine H, Schlossman S F
出版信息
J Exp Med. 1978 Feb 1;147(2):605-10. doi: 10.1084/jem.147.2.605.
Abstract
Peripheral human T cells, isolated by sheep erythrocyte-rosette formation and density centrifugation, were highly cytotoxic to both Ab-coated autologous lymphocytes and antibody (Ab)-coated chicken erythrocytes when stimulated in mixed lymphocyte culture, but were not lytic when freshly purified, or when unstimulated in 6-day culture. Allosensitized T cells were shown to effect this activity by a specific effector-target cell interaction dependent on Ab, as indicated by: (a) induction of killing by Ab to target cells not lysed in the absence of Ab. (b) inhibition of Ab-dependent killing by aggregated Ig. The mechanism by which allosensitized T cells effect antibody-dependent cellular cytotoxicity is discussed.
摘要
通过绵羊红细胞花环形成和密度离心分离的外周人T细胞，在混合淋巴细胞培养中受到刺激时，对抗体包被的自体淋巴细胞和抗体（Ab）包被的鸡红细胞均具有高度细胞毒性，但在新鲜纯化时或在6天培养中未受刺激时则无细胞溶解作用。同种致敏T细胞通过依赖抗体的特异性效应细胞-靶细胞相互作用发挥这种活性，如下所示：（a）抗体诱导对在无抗体时不被裂解的靶细胞的杀伤作用。（b）聚集的免疫球蛋白抑制抗体依赖性杀伤作用。本文讨论了同种致敏T细胞发挥抗体依赖性细胞毒性的机制。
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本文引用的文献
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Cytotoxic lymphocytes from rats depleted of thymus processed cells.来自胸腺处理细胞耗竭的大鼠的细胞毒性淋巴细胞。
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Nat New Biol. 1973 Mar 28;242(117):111-3. doi: 10.1038/newbio242111a0.
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