Erkiliç Suna, Ozsaraç Coşkun, Küllü Sevgi
Department of Pathology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey.
Acta Cytol. 2003 Nov-Dec;47(6):1023-7. doi: 10.1159/000326639.
To compare the sputum smear cytology and cell block methods for specimen adequacy, cytology quality and diagnostic accuracy in the diagnosis of lung cancer.
We assessed 2,524 sputum specimens from 768 patients. The specimens were prepared as smears and cell blocks for cytopathologic examination between March 1, 1992, and December 31, 1998. The smear and cell block slides were evaluated both separately and together, and the results were compared with radiologic and histopathologic diagnoses.
The sensitivity of the smear method was 69.4% and specificity was 99.5%. The sensitivity of the cell block method was 84.4% and specificity, 100%. The sensitivity of the smear and cell block together was 87.6% and specificity, 99.5%.
The cell block method increases the sensitivity and specificity of sputum cytology, and when smear and cell block slides are evaluated together, sensitivity reaches its highest value. Therefore, application of smear and cell block methods together seems most useful in the diagnosis of lung cancer.
比较痰涂片细胞学检查和细胞块法在肺癌诊断中样本充足率、细胞学质量及诊断准确性方面的差异。
我们评估了768例患者的2524份痰标本。在1992年3月1日至1998年12月31日期间，将这些标本制成涂片和细胞块用于细胞病理学检查。分别对涂片和细胞块玻片进行评估，并将结果与放射学和组织病理学诊断结果进行比较。
涂片法的敏感性为69.4%，特异性为99.5%。细胞块法的敏感性为84.4%，特异性为100%。涂片和细胞块联合使用的敏感性为87.6%，特异性为99.5%。
细胞块法提高了痰细胞学检查的敏感性和特异性，当同时评估涂片和细胞块玻片时，敏感性达到最高值。因此，涂片和细胞块法联合应用在肺癌诊断中似乎最有用。
