Montanaro Fabio, Bray Freddie, Gennaro Valerio, Merler Enzo, Tyczynski Jerzy E, Parkin Donald Maxwell, Strnad Marija, Jechov'a Marie, Storm Hans H, Aareleid Tiiu, Hakulinen Timo, Velten Michel, Lef'evre Hacina, Danzon Arlette, Buemi Antoine, Daur'es Jean-Pierre, Ménégoz François, Raverdy Nicole, Sauvage Martine, Ziegler Hartwig, Comber Harry, Paci Eugenio, Vercelli Marina, De Lisi Vincenzo, Tumino Rosario, Zanetti Roberto, Berrino Franco, Stanta Giorgio, Langmark Frøydis, Rachtan Jadwiga, Mezyk Ryszard, Blaszczyk Jerzy, Ivan Plesko, Primic-Zakelj Maja, Martínez Alvaro Cañada, Izarzugaza Isabel, Borràs Joan, Garcia Carmen Martínez, Garau Isabel, Sánchez Navarro Carmen, Aicua Ardanaz, Barlow Lotti, Torhorst Joachim, Bouchardy Christine, Levi Fabio, Fisch Thomas, Probst Nicole, Visser Otto, Quinn Mike, Gavin Anna, Brewster David, Mikov Marica
Mesothelioma Registry of Liguria, Unit of Environmental Epidemiology and Applied Biostatistics, National Cancer Research Institute (IST), Genova, Italy.
Cancer Causes Control. 2003 Oct;14(8):791-803. doi: 10.1023/a:1026300619747.
To summarize the geographical and temporal variations in incidence of pleural mesothelioma in Europe, using the extensive data available from European general cancer registries, and consider these in light of recent trends in asbestos extraction, use and import in European countries.
The data were extracted from the European Cancer Incidence and Mortality database (EUROCIM). The inclusion criteria was acceptance in Volume VII of Cancer Incidence in Five Continents. Truncated age-standardized rates per 100,000 for the ages 40-74 were used to summarise recent geographical variations. Standardized rate ratios and 95% confidence intervals for the periods 1986-1990 and 1991-1995 were compared to assess geographical variations in risk. To investigate changes in the magnitude of most recent trends, regression models fitted to the latest available 10-year period (1988-1997) were compared with trends in the previous decade. Fitted rates in younger (40-64) and older adults (65-74) in the most recent period were also compared.
There was a great deal of geographical variation in the risk of mesothelioma, annual rates ranging from around 8 per 100,000 in Scotland, England and The Netherlands, to lower than 1 per 100,000 in Spain (0.96), Estonia (0.85), Poland (0.85) and Yugoslavia, Vojvodina (0.56) among men. The rank of the rates for women was similar to that observed for men, although rates were considerably lower. Between 1978 and 1987, rates in men significantly increased in all countries (excepting Denmark). In the following 10 years, there was a deceleration in trend, and a significant increase was detectable only in England and France. In addition, the magnitude of recent trends in younger men was generally lower than those estimated for older men, in both national and regional cancer registry settings.
While mesothelioma incidence rates are still rising in Europe, a deceleration has started in some countries. A decrease may begin in the next few years in certain European populations considering the deceleration of observed trends in mesothelioma and asbestos exposure, as well as the recent ban on its use.
利用欧洲普通癌症登记处提供的大量数据，总结欧洲胸膜间皮瘤发病率的地理和时间变化，并结合欧洲国家近期石棉开采、使用和进口趋势进行分析。
数据取自欧洲癌症发病率和死亡率数据库（EUROCIM）。纳入标准为被收录在《五大洲癌症发病率》第七卷中。采用每10万人中40 - 74岁年龄段的截断年龄标准化发病率来总结近期的地理差异。比较1986 - 1990年和1991 - 1995年期间的标准化率比及95%置信区间，以评估风险的地理差异。为研究最近趋势的幅度变化，将拟合到最新可得的10年期间（1988 - 1997年）的回归模型与前十年的趋势进行比较。还比较了最近时期内较年轻（40 - 64岁）和较年长成年人（65 - 74岁）的拟合发病率。
间皮瘤风险存在很大的地理差异，男性年发病率从苏格兰、英格兰和荷兰的每10万人约8例，到西班牙（0.96）、爱沙尼亚（0.85）、波兰（0.85）和南斯拉夫伏伊伏丁那（0.56）低于每10万人1例。女性发病率排名与男性相似，尽管发病率低得多。1978年至1987年期间，所有国家（丹麦除外）男性发病率显著上升。在接下来的10年里，趋势有所减缓，仅在英格兰和法国可检测到显著上升。此外，在国家和地区癌症登记处，较年轻男性最近趋势的幅度通常低于较年长男性。
虽然欧洲间皮瘤发病率仍在上升，但一些国家已开始出现减缓。考虑到间皮瘤和石棉暴露趋势的减缓以及最近对石棉使用的禁令，未来几年某些欧洲人群的发病率可能开始下降。
Zotero 插件