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催化位点图谱：一个利用结构数据在酶中鉴定出的催化位点和残基的资源库。

The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data.

作者信息

Porter Craig T, Bartlett Gail J, Thornton Janet M

机构信息

EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

出版信息

Nucleic Acids Res. 2004 Jan 1;32(Database issue):D129-33. doi: 10.1093/nar/gkh028.

DOI:10.1093/nar/gkh028
PMID:14681376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC308762/
Abstract

The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/thornton-srv/databases/CSA. The database consists of two types of annotated site: an original hand-annotated set containing information extracted from the primary literature, using defined criteria to assign catalytic residues, and an additional homologous set, containing annotations inferred by PSI-BLAST and sequence alignment to one of the original set. The CSA can be queried via Swiss-Prot identifier and EC number, as well as by PDB code. CSA Version 1.0 contains 177 original hand- annotated entries and 2608 homologous entries, and covers approximately 30% of all EC numbers found in PDB. The CSA will be updated on a monthly basis to include homologous sites found in new PDBs, and new hand-annotated enzymes as and when their annotation is completed.

摘要

催化位点图谱（CSA）为蛋白质数据库中的酶提供催化残基注释。可通过http://www.ebi.ac.uk/thornton-srv/databases/CSA在线获取该图谱。该数据库由两种类型的注释位点组成：一个原始的人工注释集，包含从原始文献中提取的信息，使用定义的标准来指定催化残基；另一个是额外的同源集，包含通过PSI-BLAST推断的注释以及与原始集中的一个进行序列比对的结果。CSA可通过Swiss-Prot标识符、酶委员会（EC）编号以及蛋白质数据银行（PDB）代码进行查询。CSA 1.0版本包含177个原始人工注释条目和2608个同源条目，覆盖了PDB中约30%的所有EC编号。CSA将每月更新，以纳入新PDB中发现的同源位点以及新完成注释的人工注释酶。

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