Hermjakob Henning, Montecchi-Palazzi Luisa, Lewington Chris, Mudali Sugath, Kerrien Samuel, Orchard Sandra, Vingron Martin, Roechert Bernd, Roepstorff Peter, Valencia Alfonso, Margalit Hanah, Armstrong John, Bairoch Amos, Cesareni Gianni, Sherman David, Apweiler Rolf
European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D452-5. doi: 10.1093/nar/gkh052.
IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains approximately 2200 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact.
IntAct提供了一个用于存储、展示和分析蛋白质相互作用的开源数据库及工具包。其网络界面提供了蛋白质相互作用的文本和图形表示,并允许在相互作用蛋白质的基因本体(GO)注释背景下探索相互作用网络。一个网络服务允许直接通过计算以XML格式检索相互作用网络。IntAct目前包含从文献中导入并与Swiss-Prot团队合作整理的约2200个二元和复杂相互作用,大量使用受控词汇表以确保数据一致性。所有IntAct软件、数据和受控词汇表均可在http://www.ebi.ac.uk/intact获取。