已报告的沙门氏菌感染疫情中感染剂量与疾病严重程度之间的关系。
The relationship between infecting dose and severity of disease in reported outbreaks of Salmonella infections.
作者信息
Glynn J R, Bradley D J
机构信息
Tropical Health Epidemiology Unit, London School of Hygiene and Tropical Medicine, London.
出版信息
Epidemiol Infect. 1992 Dec;109(3):371-88. doi: 10.1017/s0950268800050366.
The relationship between size of the infecting dose and severity of the resulting disease has been investigated for salmonella infections by reanalysis of data within epidemics for 32 outbreaks, and comparing data between outbreaks for 68 typhoid epidemics and 49 food-poisoning outbreaks due to salmonellas. Attack rate, incubation period, amount of infected food consumed and type of vehicle are used as proxy measures of infecting dose, while case fatality rates for typhoid and case hospitalization rates for food poisoning salmonellas were used to assess severity. Limitations of the data are discussed. Both unweighted and logit analysis models are used. There is no evidence for a dose-severity relationship for Salmonella typhi, but evidence of a correlation between dose and severity is available from within-epidemic or between-epidemic analysis, or both, for Salmonella typhimurium, S. enteritidis, S. infantis, S. newport, and S. thompson. The presence of such a relationship affects the way in which control interventions should be assessed.
通过重新分析32次沙门氏菌感染疫情的数据，并比较68次伤寒疫情和49次沙门氏菌引起的食物中毒疫情之间的数据，研究了感染剂量大小与由此产生疾病的严重程度之间的关系。攻击率、潜伏期、食用的受感染食物量和传播媒介类型被用作感染剂量的替代指标，而伤寒的病死率和食物中毒沙门氏菌的病例住院率则用于评估严重程度。讨论了数据的局限性。使用了未加权和logit分析模型。没有证据表明伤寒杆菌存在剂量-严重程度关系，但对于鼠伤寒沙门氏菌、肠炎沙门氏菌、婴儿沙门氏菌、纽波特沙门氏菌和汤普森沙门氏菌，在疫情内部或疫情之间的分析中，或两者兼而有之，可以得到剂量与严重程度之间存在相关性的证据。这种关系的存在会影响控制干预措施的评估方式。
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