Nilsson L, Verbeek H, Hoffmann U, Haupt M, Bosch L
Department of Cell Biology, Arrhenius Laboratories, Stockholm University, Sweden.
FEMS Microbiol Lett. 1992 Nov 15;78(1):85-8. doi: 10.1016/0378-1097(92)90292-v.
The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli. In this report the growth behaviour of a fis bacterium was studied under steady-state conditions and in competition experiments with a wild-type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.
