Cserr H F, DePasquale M, Harling-Berg C J, Park J T, Knopf P M
Section of Physiology, Brown University, Providence, RI 02912.
J Neuroimmunol. 1992 Dec;41(2):195-202. doi: 10.1016/0165-5728(92)90070-2.
Cerebrospinal fluid (CSF) and serum antibody responses to albumin administered into CSF or muscle have been compared with respect to titer, isotype profile and complement-fixing activity in a rat model with normal brain barrier function. CSF/serum titer ratios and the ratio of IgG subclasses, IgG1/IgG2, were both elevated following CSF immunization. In contrast, there was no difference in complement-fixing activity between antibodies elicited by the two routes of immunization. It is suggested that intrathecal antibody synthesis accounts for the elevated CSF antibody titers in CSF-immunized rats, providing the first example of central nervous system antibody synthesis in an animal with normal brain barrier permeability.
在具有正常脑屏障功能的大鼠模型中，已就滴度、同种型谱和补体固定活性对注入脑脊液或肌肉的白蛋白的脑脊液（CSF）和血清抗体反应进行了比较。脑脊液免疫后，脑脊液/血清滴度比值以及IgG亚类的比值IgG1/IgG2均升高。相比之下，两种免疫途径引发的抗体之间的补体固定活性没有差异。提示鞘内抗体合成导致脑脊液免疫大鼠的脑脊液抗体滴度升高，这为具有正常脑屏障通透性的动物中枢神经系统抗体合成提供了首个实例。
