Andrews F M, Geiser D R, Sommardahl C S, Green E M, Provenza M
Department of Rural Practice, University of Tennessee, College of Veterinary Medicine, Knoxville 39701-1071.
Am J Vet Res. 1994 Jun;55(6):741-5.
Total protein (TP), albumin, and IgG concentrations were measured in CSF from the atlanto-occipital (AO) and lumbosacral (LS) sites and in serum of 15 clinically normal neonatal foals < or = 10 days old (mean, 7.0 days). The albumin quotient (AQ; CSF albumin/serum albumin x 100) and IgG index ([CSF IgG/serum IgG] x [serum albumin/CSF albumin]), indicators of blood-brain barrier permeability and intrathecal IgG production, respectively, were then calculated. Mean +/- SD values obtained from the foals of this study were: serum albumin, 2,900 +/- 240 mg/dl; serum IgG, 1,325 +/- 686 mg/dl; AO CSF total protein (TP), 82.8 +/- 19.2 mg/dl; LS CSF TP, 83.6 +/- 16.1 mg/dl; AO CSF albumin, 52.0 +/- 8.6 mg/dl; LS CSF albumin, 53.8 +/- 15.7 mg/dl; AO CSF IgG, 10.2 +/- 5.5 mg/dl; LS CSF IgG, 9.9 +/- 5.7 mg/dl; AO AQ, 1.86 +/- 0.29; LS AQ, 1.85 +/- 0.51, AO IgG index, 0.52 +/- 0.28; and LS IgG index, 0.48 +/- 0.27. Significant difference between values for the AO and LS sites was not found. A CSF albumin concentration > 85.2 mg/dl or AQ > 2.4, as determined by mean +/- 2 SD, may indicate increased blood-brain barrier permeability. An IgG index value > 1.0 may indicate intrathecal IgG production. Values obtained for foals of this study should serve as baseline for comparison in the evaluation of blood-brain barrier permeability and intrathecal IgG production in neonatal foals with neurologic disease.
在15匹年龄小于或等于10日龄（平均7.0日龄）临床正常的新生马驹中，测量了寰枕（AO）和腰骶（LS）部位脑脊液以及血清中的总蛋白（TP）、白蛋白和IgG浓度。然后计算白蛋白商（AQ；脑脊液白蛋白/血清白蛋白×100）和IgG指数（[脑脊液IgG/血清IgG]×[血清白蛋白/脑脊液白蛋白]），分别作为血脑屏障通透性和鞘内IgG产生的指标。本研究马驹获得的均值±标准差如下：血清白蛋白，2900±240mg/dl；血清IgG，1325±686mg/dl；AO脑脊液总蛋白（TP），82.8±19.2mg/dl；LS脑脊液TP，83.6±16.1mg/dl；AO脑脊液白蛋白，52.0±8.6mg/dl；LS脑脊液白蛋白，53.8±15.7mg/dl；AO脑脊液IgG，10.2±5.5mg/dl；LS脑脊液IgG，9.9±5.7mg/dl；AO AQ，1.86±0.29；LS AQ，1.85±0.51；AO IgG指数，0.52±0.28；LS IgG指数，0.48±0.27。未发现AO和LS部位数值之间存在显著差异。通过均值±2标准差确定，脑脊液白蛋白浓度>85.2mg/dl或AQ>2.4可能表明血脑屏障通透性增加。IgG指数值>1.0可能表明鞘内IgG产生。本研究马驹获得的数值应作为评估患有神经系统疾病的新生马驹血脑屏障通透性和鞘内IgG产生的比较基线。
