Harling-Berg C, Knopf P M, Merriam J, Cserr H F
Section of Physiology and Biophysics, Brown University, Providence, RI 02912.
J Neuroimmunol. 1989 Dec;25(2-3):185-93. doi: 10.1016/0165-5728(89)90136-7.
The humoral immune response to human serum albumin (HSA) microinfused into cerebrospinal fluid (CSF) has been measured in serum, cervical lymph nodes, and spleen of Sprague-Dawley rats. Conditions were designed to promote normal brain barrier function. Serum titers of anti-HSA antibodies, primarily IgG, increased over 10 days and then persisted for at least 10 weeks. A significant role for cervical lymphatics in the systemic response to CSF-administered HSA is suggested, based on results showing that (1) cervical lymph obstruction reduces serum titers of anti-HSA antibodies, and (2) total antibody production by combined superficial and deep cervical nodes, sampled 14 days post-immunization, exceeds that by the spleen.
已在Sprague-Dawley大鼠的血清、颈部淋巴结和脾脏中测量了对微量注入脑脊液（CSF）的人血清白蛋白（HSA）的体液免疫反应。实验条件旨在促进正常的脑屏障功能。抗HSA抗体的血清滴度，主要是IgG，在10天内升高，然后持续至少10周。基于以下结果表明颈部淋巴管在对脑脊液给予的HSA的全身反应中起重要作用：（1）颈部淋巴阻塞降低了抗HSA抗体的血清滴度，以及（2）免疫后14天采集的颈部浅表和深部淋巴结联合产生的总抗体超过脾脏产生的总抗体。
