Cahn-Weiner Deborah A, Malloy Paul F, Rebok George W, Ott Brian R
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA.
Appl Neuropsychol. 2003;10(4):215-23. doi: 10.1207/s15324826an1004_3.
The efficacy of a memory-training program to improve word-list recall and recognition was evaluated in 34 patients with probable Alzheimer's disease (AD). The patients, who were all taking donepezil throughout the 6-week intervention, were randomly assigned to a cognitive intervention group or a control group. The Control group received didactic presentations but no formal memory training. Patients were assessed on neuropsychological tests before the 6-week training program, immediately after the training, and 8 weeks after completion of the training. Caregivers, who were blind to group assignment, completed activities of daily living (ADLs) and everyday memory questionnaires at all three time-points. No significant main effects of group (training vs. control) or time were observed on any outcome measures, nor were any significant interactions found. In terms of "process" measures during the 6-week training program, the patients demonstrated modest improvement on recall and recognition of test material presented during the training sessions. These results suggest that although modest gains in learning and memory may be evident in AD patients who are taught specific strategies, the benefits do not generalize to other measures of neuropsychological functioning after a brief intervention.
在34名可能患有阿尔茨海默病（AD）的患者中评估了一项记忆训练计划对改善单词列表回忆和识别能力的效果。在为期6周的干预期间，所有患者都服用多奈哌齐，他们被随机分配到认知干预组或对照组。对照组接受了说教式讲解，但没有进行正式的记忆训练。在为期6周的训练计划之前、训练结束后立即以及训练完成8周后，对患者进行神经心理学测试。对分组不知情的护理人员在所有三个时间点完成日常生活活动（ADL）和日常记忆问卷。在任何结果测量中，均未观察到组（训练组与对照组）或时间的显著主效应，也未发现任何显著的交互作用。就为期6周的训练计划中的“过程”测量而言，患者在训练期间呈现的测试材料的回忆和识别方面有适度改善。这些结果表明，尽管在接受特定策略教导的AD患者中，学习和记忆可能会有适度提高，但在短暂干预后，这些益处并未推广到神经心理学功能的其他测量指标上。
