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在致敏淋巴细胞试验中是否存在显著的基因剂量效应?

Is there a significant gene dose effect in the primed lymphocyte test?

作者信息

Pawelec G, Bradley B A, Puntis M C

出版信息

Tissue Antigens. 1977 Nov;10(5):353-60. doi: 10.1111/j.1399-0039.1977.tb00770.x.

Abstract

Pig lymphocytes typed for products of the MHC were primed in vitro against allogeneic lymphocytes. When rechallenged with a panel of different cells, specific 'typing' responses were distinguishable which were not obscured by high non-specific responses or by a restimulator gene dose effect. A gene additive effect was observed in both primary MLR and in the primed lymphocyte test (PLT).

摘要

对主要组织相容性复合体(MHC)产物进行分型的猪淋巴细胞在体外针对同种异体淋巴细胞进行致敏。当用一组不同的细胞再次刺激时,可以区分出特异性的“分型”反应,这些反应不会被高非特异性反应或再刺激基因剂量效应所掩盖。在原发性混合淋巴细胞反应(MLR)和致敏淋巴细胞试验(PLT)中均观察到基因加性效应。

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