嗜铁素还原地杆菌的染色体编码安布勒D类β-内酰胺酶作为碳青霉烯水解氧头孢烯酶的前身。
Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase.
作者信息
Poirel Laurent, Héritier Claire, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, Université Paris XI, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France.
出版信息
Antimicrob Agents Chemother. 2004 Jan;48(1):348-51. doi: 10.1128/AAC.48.1.348-351.2004.
Abstract
A chromosome-encoded beta-lactamase gene from a Shewanella oneidensis reference strain was cloned and expressed in Escherichia coli. It encoded a carbapenem-hydrolyzing Ambler class D beta-lactamase, OXA-54, that shared 92% amino acid identity with the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 from Klebsiella pneumoniae. This work suggests that Shewanella spp. may produce the progenitor of oxacillinases compromising the efficacy of imipenem in clinically relevant gram-negative pathogens.
摘要
从希瓦氏菌参考菌株中克隆出一个染色体编码的β-内酰胺酶基因，并在大肠杆菌中进行表达。它编码一种可水解碳青霉烯的安布勒D类β-内酰胺酶OXA-54，该酶与肺炎克雷伯菌中质粒编码的可水解碳青霉烯的苯唑西林酶OXA-48有92%的氨基酸同一性。这项研究表明，希瓦氏菌属可能产生了苯唑西林酶的祖系，从而影响了亚胺培南在临床相关革兰氏阴性病原体中的疗效。
相似文献
1
Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase.嗜铁素还原地杆菌的染色体编码安布勒D类β-内酰胺酶作为碳青霉烯水解氧头孢烯酶的前身。
Antimicrob Agents Chemother. 2004 Jan;48(1):348-51. doi: 10.1128/AAC.48.1.348-351.2004.
2
Genetic and biochemical characterization of a chromosome-encoded carbapenem-hydrolyzing ambler class D beta-lactamase from Shewanella algae.来自海藻希瓦氏菌的一种染色体编码的碳青霉烯水解性安布勒D类β-内酰胺酶的遗传和生化特性分析
Antimicrob Agents Chemother. 2004 May;48(5):1670-5. doi: 10.1128/AAC.48.5.1670-1675.2004.
3
Origin of OXA-181, an emerging carbapenem-hydrolyzing oxacillinase, as a chromosomal gene in Shewanella xiamenensis.OXA-181 的起源是一种新型的碳青霉烯水解头孢菌素酶，它是厦门希瓦氏菌染色体基因。
Antimicrob Agents Chemother. 2011 Sep;55(9):4405-7. doi: 10.1128/AAC.00681-11. Epub 2011 Jul 11.
4
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.肺炎克雷伯菌中出现由苯唑西林酶介导的对亚胺培南的耐药性。
Antimicrob Agents Chemother. 2004 Jan;48(1):15-22. doi: 10.1128/AAC.48.1.15-22.2004.
5
CTX-M-15-Producing Shewanella Species Clinical Isolate Expressing OXA-535, a Chromosome-Encoded OXA-48 Variant, Putative Progenitor of the Plasmid-Encoded OXA-436.产CTX-M-15 耐碳青霉烯类肺炎克雷伯菌中表达的 OXA-535 为染色体编码的 OXA-48 变体，可能是质粒编码的 OXA-436 的前体。
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01879-17. Print 2018 Jan.
6
Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France.VIM-2的特性研究，VIM-2是一种可水解碳青霉烯类的金属β-内酰胺酶及其来自法国一株铜绿假单胞菌临床分离株的质粒和整合子携带基因。
Antimicrob Agents Chemother. 2000 Apr;44(4):891-7. doi: 10.1128/AAC.44.4.891-897.2000.
7
Biochemical properties of a carbapenem-hydrolyzing beta-lactamase from Enterobacter cloacae and cloning of the gene into Escherichia coli.阴沟肠杆菌碳青霉烯水解β-内酰胺酶的生化特性及其基因克隆至大肠杆菌
Antimicrob Agents Chemother. 1993 May;37(5):939-46. doi: 10.1128/AAC.37.5.939.
8
Genetic and Biochemical Characterization of OXA-535, a Distantly Related OXA-48-Like β-Lactamase.OXA-535 基因和生化特性分析：一种与 OXA-48 关系较远的 OXA 类β-内酰胺酶
Antimicrob Agents Chemother. 2018 Sep 24;62(10). doi: 10.1128/AAC.01198-18. Print 2018 Oct.
9
OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii.OXA-60，一种来自皮氏罗尔斯通氏菌的染色体介导的、可诱导的、能水解亚胺培南的D类β-内酰胺酶。
Antimicrob Agents Chemother. 2004 Nov;48(11):4217-25. doi: 10.1128/AAC.48.11.4217-4225.2004.
10
Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.鲍曼不动杆菌染色体编码的碳青霉烯水解型苯唑西林酶OXA-40的遗传与功能分析
Antimicrob Agents Chemother. 2003 Jan;47(1):268-73. doi: 10.1128/AAC.47.1.268-273.2003.
引用本文的文献
1
Genetic insights into spp., progenitor of the -like genes: a large-scale study.关于 - 样基因的祖先 spp. 的遗传学见解：一项大规模研究。 （你提供的原文中部分物种名称缺失，这可能会影响译文的完整理解，以上是基于现有内容的翻译。）
Microb Genom. 2025 Jun;11(6). doi: 10.1099/mgen.0.001417.
2
Characterization of Antibiotic Resistance in Species: An Emerging Pathogen in Clinical and Environmental Settings.物种中抗生素耐药性的特征：临床和环境中的一种新兴病原体。
Microorganisms. 2025 May 13;13(5):1115. doi: 10.3390/microorganisms13051115.
3
Comparative Genomics Identified PenR E151V Substitution Associated with Carbapenem-Resistance Complex and a Novel Complex Specific OXA-1043 Subgroup.比较基因组学鉴定出与碳青霉烯耐药复合体相关的PenR E151V替换以及一个新型的复合体特异性OXA-1043亚组。
Infect Drug Resist. 2023 Aug 28;16:5627-5635. doi: 10.2147/IDR.S418969. eCollection 2023.
4
An overview of carbapenem-resistant organisms from food-producing animals, seafood, aquaculture, companion animals, and wildlife.来自食用动物、海鲜、水产养殖、伴侣动物和野生动物的耐碳青霉烯类微生物概述。
Front Vet Sci. 2023 Jun 15;10:1158588. doi: 10.3389/fvets.2023.1158588. eCollection 2023.
5
Unveiling the Emergence and Genetic Diversity of OXA-48-like Carbapenemase Variants in .揭示……中OXA - 48样碳青霉烯酶变体的出现及基因多样性
Microorganisms. 2023 May 18;11(5):1325. doi: 10.3390/microorganisms11051325.
6
Polluted wetlands contain multidrug-resistance plasmids encoding CTX-M-type extended-spectrum β-lactamases.受污染湿地中含有携带 CTX-M 型超广谱β-内酰胺酶的多重耐药质粒。
Plasmid. 2023 May;126:102682. doi: 10.1016/j.plasmid.2023.102682. Epub 2023 Apr 4.
7
NDM-1 and OXA-48-Like Carbapenemases (OXA-48, OXA-181 and OXA-252) Co-Producing from Hospital Wastewater, China.中国医院废水中同时产生的NDM-1和OXA-48样碳青霉烯酶（OXA-48、OXA-181和OXA-252）
Infect Drug Resist. 2022 Nov 29;15:6927-6938. doi: 10.2147/IDR.S386345. eCollection 2022.
8
infection in humans: Epidemiology, clinical features and pathogenicity.人类感染：流行病学、临床特征和致病性。
Virulence. 2022 Dec;13(1):1515-1532. doi: 10.1080/21505594.2022.2117831.
9
OXA-48-Like β-Lactamases: Global Epidemiology, Treatment Options, and Development Pipeline.OXA-48 类β-内酰胺酶：全球流行病学、治疗选择和研发管道。
Antimicrob Agents Chemother. 2022 Aug 16;66(8):e0021622. doi: 10.1128/aac.00216-22. Epub 2022 Jul 20.
10
Detection by metagenomic functional analysis and improvement by experimental evolution of β-lactams resistance genes present in oil contaminated soils.通过宏基因组功能分析检测和通过实验进化来提高油污染土壤中存在的β-内酰胺类抗生素抗性基因。
Sci Rep. 2022 Jun 29;12(1):10059. doi: 10.1038/s41598-022-13883-x.
本文引用的文献
1
ARI 1: beta-lactamase-mediated imipenem resistance in Acinetobacter baumannii.鲍曼不动杆菌中β-内酰胺酶介导的碳青霉烯类耐药性。
Int J Antimicrob Agents. 1993 Feb;2(2):81-7. doi: 10.1016/0924-8579(93)90045-7.
2
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.肺炎克雷伯菌中出现由苯唑西林酶介导的对亚胺培南的耐药性。
Antimicrob Agents Chemother. 2004 Jan;48(1):15-22. doi: 10.1128/AAC.48.1.15-22.2004.
3
Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.鲍曼不动杆菌染色体编码的碳青霉烯水解型苯唑西林酶OXA-40的遗传与功能分析
Antimicrob Agents Chemother. 2003 Jan;47(1):268-73. doi: 10.1128/AAC.47.1.268-273.2003.
4
Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis.异化金属离子还原菌嗜铁素还原希瓦氏菌的基因组序列。
Nat Biotechnol. 2002 Nov;20(11):1118-23. doi: 10.1038/nbt749. Epub 2002 Oct 7.
5
Emerging carbapenemases in Gram-negative aerobes.革兰氏阴性需氧菌中新型碳青霉烯酶的出现。
Clin Microbiol Infect. 2002 Jun;8(6):321-31. doi: 10.1046/j.1469-0691.2002.00401.x.
6
Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support.获得性碳青霉烯水解β-内酰胺酶及其基因支持。
Curr Pharm Biotechnol. 2002 Jun;3(2):117-27. doi: 10.2174/1389201023378427.
7
Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis.奇异变形杆菌中染色体编码的D类β-内酰胺酶OXA-23
Antimicrob Agents Chemother. 2002 Jun;46(6):2004-6. doi: 10.1128/AAC.46.6.2004-2006.2002.
8
The IntI-like tyrosine recombinase of Shewanella oneidensis is active as an integron integrase.希瓦氏菌属的类整合酶酪氨酸重组酶作为整合子整合酶具有活性。
J Bacteriol. 2002 Mar;184(6):1811-5. doi: 10.1128/JB.184.6.1811-1815.2002.
9
Reconstitution of the trimethylamine oxide reductase regulatory elements of Shewanella oneidensis in Escherichia coli.在大肠杆菌中重建希瓦氏菌三甲胺氧化物还原酶调控元件
J Bacteriol. 2002 Mar;184(5):1262-9. doi: 10.1128/JB.184.5.1262-1269.2002.
10
Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.铜绿假单胞菌中苯唑西林酶介导的对头孢吡肟耐药及对头孢他啶敏感
Antimicrob Agents Chemother. 2001 Jun;45(6):1615-20. doi: 10.1128/AAC.45.6.1615-1620.2001.
Zotero 插件