Meissner Winfried, Weiss Thomas, Trippe Ralf H, Hecht Holger, Krapp Clemens, Miltner Wolfgang H
Departments of *Anesthesiology and Intensive Care and †Biological and Clinical Psychology, Friedrich Schiller University Jena, Jena, Germany.
Anesth Analg. 2004 Jan;98(1):141-147. doi: 10.1213/01.ANE.0000096191.07929.44.
The effect of acupuncture on pain perception is controversial. Because late amplitudes of somatosensory evoked potentials (SEPs) to noxious stimuli are thought to correlate with the subjective experience of pain intensity, we designed this study to detect changes of these SEPs before and after acupuncture in a double-blinded fashion. Sixteen volunteers were anesthetized by propofol and exposed to painful electric stimuli to the right forefinger. Then, blinded to the research team, the acupuncture group (n = 8) was treated with electric needle acupuncture over 15 min at analgesic points of the leg, whereas the sham group (n = 8) received no treatment. Thereafter, nociceptive stimulation was repeated. SEPs were recorded during each noxious stimulation from the vertex Cz, and latencies and amplitudes of the N150 and P260 components were analyzed by analysis of variance. P260 amplitudes decreased from 4.40 +/- 2.76 microV (mean +/- SD) before treatment to 1.67 +/- 1.21 microV after treatment (P < 0.05), whereas amplitudes of the sham group remained unchanged (2.64 +/- 0.94 microV before versus 2.54 +/- 1.54 microV after treatment). In conclusion, this double-blinded study demonstrated that electric needle acupuncture, as compared with sham treatment, significantly decreased the magnitudes of late SEP amplitudes with electrical noxious stimulation in anesthetized subjects, suggesting a specific analgesic effect of acupuncture.
This double-blinded study demonstrates that electric needle acupuncture, as compared with sham treatment, significantly decreases the magnitudes of late somatosensory evoked potential amplitudes with electrical noxious stimulation in anesthetized subjects, suggesting a specific analgesic effect of acupuncture.
针刺对疼痛感知的影响存在争议。由于对有害刺激的体感诱发电位（SEP）晚期波幅被认为与疼痛强度的主观体验相关，我们设计了本研究以双盲方式检测针刺前后这些SEP的变化。16名志愿者接受丙泊酚麻醉，右食指接受疼痛性电刺激。然后，对研究团队设盲，针刺组（n = 8）在腿部镇痛穴位接受电针治疗15分钟，而假手术组（n = 8）不接受治疗。此后，重复伤害性刺激。在每次有害刺激期间从头顶Cz记录SEP，通过方差分析分析N150和P260成分的潜伏期和波幅。P260波幅从治疗前的4.40±2.76 μV（平均值±标准差）降至治疗后的1.67±1.21 μV（P <0.05），而假手术组的波幅保持不变（治疗前2.64±0.94 μV，治疗后2.54±1.54 μV）。总之，这项双盲研究表明，与假手术治疗相比，电针在麻醉受试者中通过电有害刺激显著降低了SEP晚期波幅的大小，提示针刺具有特定的镇痛作用。
这项双盲研究表明，与假手术治疗相比，电针在麻醉受试者中通过电有害刺激显著降低了体感诱发电位晚期波幅的大小，提示针刺具有特定的镇痛作用。
