Nagel E, Vilser W
Ophthalmic Private Practice, Anton-Sommer-Strasse 55, D-07407 Rudolstadt, Germany.
Br J Ophthalmol. 2004 Jan;88(1):54-6. doi: 10.1136/bjo.88.1.54.
To investigate diameter changes in retinal arterioles in response to flicker variations of the examination light.
One randomised eye of five healthy subjects (mean age 33.8 (SD 1.6) years) was examined. The arterial diameter response to flicker light (12.5 Hz, 530-600 nm, duration 20 seconds) was automatically and continuously measured online three times by retinal vessel analyser (RVA) and once offline from flash images using the VesselMap program.
An arterial diameter response to flicker light was found both by RVA and by analysis of flash images (p<0.001). The maximum induced dilation reached at the end of the flicker period was +7.4% (SD 2.4%) in the RVA measurements and +3.5% (0.8%) in the photographs (p = 0.01). In both techniques the vascular diameter overshot the baseline approximately 10 seconds. In the RVA measurements a minimum of -4.6% (1.9%) (p = 0.01) was measured 22 (4.7) seconds after the end of flicker exposure.
Flicker evoked response for retinal arterioles was found both by RVA and by analysis of flash images. The authors believe that the method is suitable for the quantitative investigation of retinal vasosclerosis, especially in association with arteriosclerotic and hypertensive systemic disease.
研究视网膜小动脉直径对检查光闪烁变化的反应。
对5名健康受试者（平均年龄33.8（标准差1.6）岁）的一只随机选择的眼睛进行检查。通过视网膜血管分析仪（RVA）在线自动连续测量动脉直径对闪烁光（12.5赫兹，530 - 600纳米，持续时间20秒）的反应3次，并使用VesselMap程序从闪光图像中离线测量1次。
通过RVA和闪光图像分析均发现动脉直径对闪烁光有反应（p<0.001）。在闪烁期结束时达到的最大诱导扩张在RVA测量中为+7.4%（标准差2.4%），在照片中为+3.5%（0.8%）（p = 0.01）。在两种技术中，血管直径在大约10秒时超过基线。在RVA测量中，在闪烁暴露结束后22（4.7）秒测量到最小值为-4.6%（1.9%）（p = 0.01）。
通过RVA和闪光图像分析均发现视网膜小动脉的闪烁诱发反应。作者认为该方法适用于视网膜血管硬化的定量研究，特别是与动脉硬化和高血压全身性疾病相关的研究。
