Patel Sunni, Shokr Hala, Greenstein Adam, Gherghel Doina
Vascular Research Laboratory, Ophthalmic Research Group, College Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.
Pharmacy Division, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.
J Clin Med. 2022 Nov 25;11(23):6962. doi: 10.3390/jcm11236962.
Aims: To investigate the microvascular function in apparently healthy individuals showing signs of early macrovascular endothelial dysfunction. Methods: Healthy participants aged between 30−55 years were recruited for the present study. Baseline measurements included body-mass index (BMI), waist-to-hip ratio (WHR), 24-h blood pressure, as well as fasted venous glucose, triglycerides (TG) and cholesterol (HDL, LDL and total). Brachial artery reactivity was measured using the flow-mediated dilation (FMD) technique and retinal vessel reactivity was assessed by using the Dynamic Retinal Vessel Analyser (DVA) in all individuals. The enrolled participants were separated in two groups, based on either a reduced (group 1: <5%—n = 53) or a normal FMD response (group 2: 7−10%—n = 47). Results: Individuals exhibiting reduced FMD responses showed a reduced baseline-corrected microvascular arterial dilation response to flickering light (p = 0.039). In addition, they also exhibited a reduced arteriolar maximum dilation (p = 0.034), as well as a longer dilation reaction time (p = 0.048) and a lower dilation amplitude (p = 0.042) when compared to those with normal FMD values. Conclusion: In otherwise healthy middle-aged individuals, early signs of vascular dysfunction are reflected simultaneously at both macro- and microvascular levels.
研究在明显健康但已出现早期大血管内皮功能障碍迹象的个体中的微血管功能。方法：招募年龄在30 - 55岁之间的健康参与者进行本研究。基线测量包括体重指数（BMI）、腰臀比（WHR）、24小时血压，以及空腹静脉血糖、甘油三酯（TG）和胆固醇（高密度脂蛋白、低密度脂蛋白和总胆固醇）。所有个体均使用血流介导的血管舒张（FMD）技术测量肱动脉反应性，并使用动态视网膜血管分析仪（DVA）评估视网膜血管反应性。根据FMD反应降低（第1组：<5%，n = 53）或正常（第2组：7 - 10%，n = 47）将入选参与者分为两组。结果：FMD反应降低的个体对闪烁光的基线校正微血管动脉舒张反应降低（p = 0.039）。此外，与FMD值正常的个体相比，他们还表现出小动脉最大舒张降低（p = 0.034）、舒张反应时间延长（p = 0.048）和舒张幅度降低（p = 0.042）。结论：在其他方面健康的中年个体中，血管功能障碍的早期迹象在大血管和微血管水平上同时得到反映。
