Iwasaki Y, Ikeda K, Shiojima T, Kinoshita M
Fourth Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
J Neurol Sci. 1992 Oct;112(1-2):147-51. doi: 10.1016/0022-510x(92)90144-a.
We have studied effects of TRH analogue, TA-0910 (3-methyl-(s)-5,6-dihydroorotyl-L-histidyl-L-prolinamide) (from Tanabe, Osaka, Japan) on explanted ventral and dorsal spinal cord cultures from 13- and 14-day-old rat embryos. TA-0910-treated cultures had significantly increased neurite outgrowth with cultures of ventral spinal cord, but not with cultures of dorsal spinal cord. The effect was dose-dependent. A possible role for TRH in amyotrophic lateral sclerosis remains to be defined.
我们研究了促甲状腺激素释放激素类似物TA - 0910（3 - 甲基 -（s）- 5,6 - 二氢乳清酸基 - L - 组氨酰 - L - 脯氨酰胺）（来自日本大阪的田边制药）对13和14日龄大鼠胚胎的腹侧和背侧脊髓外植体培养物的影响。用TA - 0910处理的培养物中，腹侧脊髓培养物的神经突生长显著增加，但背侧脊髓培养物未出现这种情况。该效应具有剂量依赖性。促甲状腺激素释放激素在肌萎缩侧索硬化症中的可能作用仍有待确定。
